Results 91 to 100 of about 847,425 (305)
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
TEAM LEADERS’ EXPERIENCES WITH RECEIVING POSITIVE FEEDBACK [PDF]
, 2014 The study focused on team leaders’ experiences with receiving positive feedback in an organization. The purpose was to understand how employees without a formal managerial position interpret receiving positive feedback.
Perttula, Juha; Lapland Rovaniemi University +1 more
core +1 more source
How Positive Feedback Shapes Adolescent Performance
, 2023 Positive feedback can lower performance. The purpose of the study is to test whether lowered performance after positive (vs. neutral) feedback can be prevented by delaying the positive feedback until after participants have mentally prepared for the ...
Eddie Brummelman, Nils Jostmann
core +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura +19 more
wiley +1 more source
Evolution of Cooperation when Feedback to Reputation Scores is Voluntary [PDF]
Reputation systems are used to facilitate interaction between strangers in one-shot social dilemmas, like transactions in e-commerce. The functioning of various reputation systems depend on voluntary feedback derived from the participants in those social
Marco A. Janssen
core
Feedback information and consumer motivation : the moderation role of positive and negative reference values in self-regulation [PDF]
, 2011 Marketers spend considerable resources to motivate people to consume their products and services as a means of goal attainment (Bagozzi and Dholakia, 1999).
Martin, Brett A.S. +4 more
core +1 more source
Zhongguo Jianchuan YanjiuObjectivesThis paper seeks to solve the problem of excessive energy consumption caused by the excessive amplitude of the rudder angle and high frequency of rudder angle change during ship course-keeping.MethodsA closed-loop gain shaping algorithm (CGSA ...
Jiaming FAN, Xianku ZHANG, Daocheng MA
doaj +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source