Results 71 to 80 of about 847,425 (305)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
eLife, 2015 The size and position of mitotic spindles is determined by the lengths of their constituent microtubules. Regulation of microtubule length requires feedback to set the balance between growth and shrinkage.
Anneke Hibbel +7 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Evolutionary Selection of Expectations in Positive and Negative Feedback Markets [PDF]
An economic environment is a feedback system, where dynamics of aggregate variables depend on individual expectations and also shape them. The type of feedback mechanism is crucial for the aggregate outcome.
Philipse, R., Hommes, C.H., Anufriev, M.
core
Integrin activation—the importance of a positive feedback
Bulletin of Mathematical Biology, 2006 Integrins mediate cell adhesion and are essential receptors for the development and functioning of multicellular organisms. Integrin activation is known to require both ligand and talin binding and to correlate with cluster formation but the activation mechanism and precise roles of these processes are not yet resolved. Here mathematical modeling, with
Iber, D, Campbell, I
openaire +5 more sources
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Empirical Evidence on Feedback Trading in Mature and Emerging Stock Markets [PDF]
We investigate the hypothesis that some participants in mature and emerging capital markets engage in feedback trading. The analysis is based on the Shiller-Sentana-Wadhwani noise trader model.
Martin T. Bohl, Pierre Siklos
core
Communicative Feedback in Response to Children’s Grammatical Errors
, 2023 Children learning their mother tongue engage in interactive communication starting from the early stages of their development. In a large-scale study of transcribed child-caregiver conversations, we investigated the role of Communicative Feedback in ...
Mitja Nikolaus +2 more
core +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
Dynamics of a state-dependent delay-differential equation
Electronic Journal of Qualitative Theory of Differential EquationsWe present a detailed study of a scalar differential equation with threshold state-dependent delayed feedback. This equation arises as a simplification of a gene regulatory model.
Tomas Gedeon +4 more
doaj +1 more source