Results 71 to 80 of about 6,596,021 (288)

The Effect of Psychological Skill Training Program and Positive Feedback on Handball Player’s Self-Efficacy Beliefs and their Shot Accuracy [PDF]

Annals of Applied Sport Science, 2022
Background. Recent research has revealed the importance of psychological skills training and various physiological exercises to improve sporting performance.
Hakan Metan, Veysel Küçük
doaj  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Functional evolution of a morphogenetic gradient

eLife, 2016
Bone Morphogenetic Proteins (BMPs) pattern the dorsal-ventral axis of bilaterian embryos; however, their roles in the evolution of body plan are largely unknown. We examined their functional evolution in fly embryos.
Chun Wai Kwan, Jackie Gavin-Smyth, Edwin L Ferguson, Urs Schmidt-Ott   +3 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Positive feedback in adiabatic logic

Electronics Letters, 1996
An adiabatic logic family is presented, which makes use of a CMOS positive feedback amplifier. The gate is based on dual rail logic and a cascade of such gates only needs three power/clock lines to operate. The positive feedback amplifier ensures high noise immunity and takes part in the energy recovery process.
A. VETULI, DI PASCOLI, STEFANO, L. M. REYNERI   +2 more
openaire   +2 more sources

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Evolutionary Selection of Expectations in Positive and Negative Feedback Markets [PDF]

An economic environment is a feedback system, where dynamics of aggregate variables depend on individual expectations and also shape them. The type of feedback mechanism is crucial for the aggregate outcome.
Philipse, R., Hommes, C.H., Anufriev, M.
core  

Integrin activation—the importance of a positive feedback

Bulletin of Mathematical Biology, 2006
Integrins mediate cell adhesion and are essential receptors for the development and functioning of multicellular organisms. Integrin activation is known to require both ligand and talin binding and to correlate with cluster formation but the activation mechanism and precise roles of these processes are not yet resolved. Here mathematical modeling, with
Iber, D, Campbell, I
openaire   +5 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Self-esteem instability in major depressive disorder: a computational analysis of expectation updating in response to performance feedback

Frontiers in Psychiatry
IntroductionMajor Depressive Disorder (MDD) is consistently associated with low self-esteem; however, how self-evaluative beliefs are updated in response to environmental feedback in MDD remains poorly understood.
Nilay Bilgin, Nilay Bilgin, Cemre Candemir, Cemre Candemir, Kaya Oguz, Kaya Oguz, Erkin Can Bilgin, Yigit Erdogan, Yigit Erdogan, Mehmet Cagdas Eker, Mehmet Cagdas Eker, Ali Saffet Gonul, Ali Saffet Gonul   +12 more
doaj   +1 more source