Results 31 to 40 of about 6,998,855 (248)

Context Aware Textual Entailment [PDF]

open access: yes, 2015
In conversations, stories, news reporting, and other forms of natural language, understanding requires participants to make assumptions (hypothesis) based on background knowledge, a process called entailment.
Arab-Khazaeli, Soha
core   +2 more sources

Positive and negative emotions underlie motivation for L2 learning

open access: yes, 2017
The role of basic emotions in SLA has been underestimated in both research and pedagogy. The present article examines 10 positive emotions (joy, gratitude, serenity, interest, hope, pride, amusement, inspiration, awe, and love) and 9 negative emotions ...
P. MacIntyre, L. Vincze
semanticscholar   +1 more source

Actuality Entailments, negation, and free choice inferences [PDF]

open access: yes, 2016
In some languages, (certain) root modals license Actuality Entailments (AEs) when they are perfective-marked. We discuss two puzzling properties of these constructions: (i) when AE-licensing modals are negated, the result entails the negation of ...
Alxatib, Sam
core   +2 more sources

A positive feedback loop bi-stably activates fibroblasts

open access: yesNature Communications, 2018
Although fibroblasts are dormant in normal tissue, they exhibit explosive activation during wound healing and perpetual activation in pathologic fibrosis and cancer stroma. The key regulatory network controlling these fibroblast dynamics is still unknown.
So-Young Yeo   +5 more
semanticscholar   +1 more source

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács   +8 more
wiley   +1 more source

Implications of Strategic Position Choices by Candidates

open access: yesConstitutional Political Economy, 2022
Abstract I examine the implications of strategic position choices by candidates under two different voting rules: Instant Runoff and Condorcet-Minimax. A neural net forecasts the chances of winning at different ideologies and candidates alter their ideology to maximize their expected utility.
openaire   +1 more source

p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming

open access: yesNature Communications, 2016
p62/Sqstm1 is a multifunctional protein involved in cell survival, growth and death, that is degraded by autophagy. Amplification of the p62/Sqstm1 gene, and aberrant accumulation and phosphorylation of p62/Sqstm1, have been implicated in tumour ...
Tetsuya Saito   +37 more
semanticscholar   +1 more source

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson   +3 more
wiley   +1 more source

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski   +9 more
wiley   +1 more source

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