Results 51 to 60 of about 6,998,855 (248)

Shared Oncogenic Pathways Implicated in Both Virus-Positive and UV-Induced Merkel Cell Carcinomas.

Journal of Investigative Dermatology, 2017
Merkel cell carcinoma (MCC) is a highly malignant neuroendocrine tumor of the skin whose molecular pathogenesis is not completely understood, despite the role that Merkel cell polyomavirus can play in 55-90% of cases.
M. C. González-Vela, S. Curiel-Olmo, S. Derdak, S. Beltran, M. Santibáñez, N. Martínez, Alfredo Castillo-Trujillo, M. Gut, Roxana E Sánchez-Pacheco, C. Almaráz, L. Cereceda, B. Llombart, A. Agraz-Doblás, J. Revert-Arce, J. L. López Guerrero, M. Mollejo, Pablo Isidro Marrón, P. Ortiz-Romero, L. Fernandez-Cuesta, I. Varela, I. Gut, L. Cerroni, M. Piris, J. Vaqué   +23 more
semanticscholar   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

LATTICE OF WEAK HYPER K-IDEALS OF A HYPER K-ALGEBRA [PDF]

, 2013
. In this note, we study the lattice structure of the class of all weak hyper K-ideals of a hyper K-algebra. We first introduce the notion of (left, right) scalar element in a hyper K-algebra which helps us to characterize the weak hyper K-ideals ...
M Bakhshi
core  

Trading under asymmetric information: Positive and normative implications [PDF]

, 2018
We study trading situations in which several principals on one side of the market compete to serve privately informed agents on the other side. In such ‘generalized screening’ settings, competitors may post mechanisms instead of prices, and the enforceability and the efficiency of the contractual relationships become difficult to evaluate.
andrea attar, claude d'aspremont
openaire   +4 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Cross-linguistic Functions of Complement Clauses in Oral Monologic Texts [PDF]

, 2016
Complement relations are widely identified as a type of subordination, which is traditionally defined as the combination of an independent clause and a dependent clause. A complement clause is traditionally defined as a dependent clause that refers to an
Morrone, Lindsay
core   +1 more source

Diverse modes of NMDA receptor positive allosteric modulation: Mechanisms and consequences

Neuropharmacology, 2017
NMDA Receptors (NMDARs) play key roles in synaptic physiology and NMDAR hypofunction has been implicated in various neurological conditions. In recent years an increasing number of positive allosteric modulators (PAMs) of NMDARs have been discovered and ...
D. Hackos, Jesse E. Hanson
semanticscholar   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Enough, too, and causal dependence [PDF]

, 2019
Enough-/too-constructions (E/T constructions) have an implicative reading: e.g., Mary was clever enough to leave early yesterday entails Mary left early yesterday. I argue that this implicative reading is not due to the lexical semantics proper of enough/
Zhang, Linmin
core   +1 more source