Results 91 to 100 of about 644,751 (309)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Note on bounded solutions to nonhomogenous linear difference equations

Electronic Journal of Differential Equations, 2017
By using a solvability method along with the contraction mapping principle quite recently has been presented an interesting method for showing the existence of a unique bounded solution to a nonhomogenous linear second-order difference equation on the
Stevo Stevic, Bratislav Iricanin, Zdenek Smarda   +2 more
doaj  

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Strong Convergence Theorems for Variational Inequalities and Split Equality Problem

Journal of Function Spaces and Applications, 2013
Let H1, H2, and H3 be real Hilbert spaces, let C⊆H1, Q⊆H2 be two nonempty closed convex sets, and let A:H1→H3, B:H2→H3 be two bounded linear operators. The split equality problem (SEP) is to find x∈C, y∈Q such that Ax=By.
Yu Jing Wu, Ru Dong Chen, Luo Yi Shi
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Fast empirical Bayesian LASSO for multiple quantitative trait locus mapping

BMC Bioinformatics, 2011
Background The Bayesian shrinkage technique has been applied to multiple quantitative trait loci (QTLs) mapping to estimate the genetic effects of QTLs on quantitative traits from a very large set of possible effects including the main and epistatic ...
Xu Shizhong, Huang Anhui, Cai Xiaodong
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Assessing the efficacy of mind mapping as a learning technique to enhance information retrieval in nursing students

Journal of Education and Health Promotion
BACKGROUND: Nursing education, rooted in conventional methods like didactic lectures and clinical experiences, is evolving to incorporate innovative learning strategies.
Mangesh Jabade, Husain Nadaf
doaj   +1 more source

Approximation for the Hierarchical Constrained Variational Inequalities over the Fixed Points of Nonexpansive Semigroups

Abstract and Applied Analysis, 2013
The purpose of the present paper is to study the hierarchical constrained variational inequalities of finding a point x* such that x*∈Ω,〈(A-γf)x*-(I-B)Sx*,x-x*〉≥0,  ∀x∈Ω, where Ω is the set of the solutions of the following variational inequality: x*∈Ϝ,〈(
Li-Jun Zhu
doaj   +1 more source