Results 61 to 70 of about 830,215 (273)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

The Maximal Regularity of Nonlinear Second-Order Hyperbolic Boundary Differential Equations

open access: yesAxioms
In this paper, we show the maximal regularity of nonlinear second-order hyperbolic boundary differential equations. We aim to show if the given second-order partial differential operator satisfies the specific ellipticity condition; additionally, if ...
Xingyu Liu
doaj   +1 more source

Korovkin Type Theorem for Sequences of Operators Depending on a Parameter

open access: yesDemonstratio Mathematica, 2015
We establish necessary and sufficient conditions for a parameter depending sequence (Ln,λ)n≥1 of positive linear operators such that (Ln,λ)n≥1 converges in the strong operator topology to its limit operator.
Finta Zoltán
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Towards the best constant in front of the Ditzian-Totik modulus of smoothness

open access: yesJournal of Inequalities and Applications, 2016
We give accurate estimates for the constants K ( A ( I ) , n , x ) = sup f ∈ A ( I ) | L n f ( x ) − f ( x ) | ω σ 2 ( f ; 1 / n ) , x ∈ I , n = 1 , 2 , … , $$ K\bigl(\mathcal{A}(I), n, x\bigr)=\sup_{f\in\mathcal{A}(I)}\frac{|L_{n} f(x)-f(x)|}{\omega_ ...
José A Adell, Alberto Lekuona
doaj   +1 more source

On Geometric Series of Positive Linear Operators

open access: yesConstructive Mathematical Analysis, 2019
We study the existence and the norm of operators obtained as power series of linear positive operators with particularization to Bernstein operators. We also obtain a Voronovskaja-kind theorem.
openaire   +3 more sources

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Multivariate and abstract approximation theory for Banach space valued functions

open access: yesDemonstratio Mathematica, 2017
Here we study quantitatively the high degree of approximation of sequences of linear operators acting on Banach space valued Fréchet differentiable functions to the unit operator, as well as other basic approximations including those under convexity ...
Anastassiou George A.
doaj   +1 more source

Solutions for a Singular Hadamard-Type Fractional Differential Equation by the Spectral Construct Analysis

open access: yesJournal of Function Spaces, 2020
In this paper, we consider the existence of positive solutions for a Hadamard-type fractional differential equation with singular nonlinearity. By using the spectral construct analysis for the corresponding linear operator and calculating the fixed point
Xinguang Zhang   +4 more
doaj   +1 more source

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