Results 71 to 80 of about 8,464,085 (281)
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
The Maximal Regularity of Nonlinear Second-Order Hyperbolic Boundary Differential Equations
AxiomsIn this paper, we show the maximal regularity of nonlinear second-order hyperbolic boundary differential equations. We aim to show if the given second-order partial differential operator satisfies the specific ellipticity condition; additionally, if ...
Xingyu Liu
doaj +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Towards the best constant in front of the Ditzian-Totik modulus of smoothness
Journal of Inequalities and Applications, 2016 We give accurate estimates for the constants K ( A ( I ) , n , x ) = sup f ∈ A ( I ) | L n f ( x ) − f ( x ) | ω σ 2 ( f ; 1 / n ) , x ∈ I , n = 1 , 2 , … , $$ K\bigl(\mathcal{A}(I), n, x\bigr)=\sup_{f\in\mathcal{A}(I)}\frac{|L_{n} f(x)-f(x)|}{\omega_ ...
José A Adell, Alberto Lekuona
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
ℐ-αβ-statistical relative uniform convergence for double sequences and its applications
Demonstratio MathematicaThis article introduces a novel concept of convergence, referred to as ℐ{\mathcal{ {\mathcal I} }}-αβ\alpha \beta -statistical relative uniform convergence, for double sequences of functions.
Bayram Nilay Sahin, Yıldız Sevda
doaj +1 more source
Multivariate and abstract approximation theory for Banach space valued functions
Demonstratio Mathematica, 2017 Here we study quantitatively the high degree of approximation of sequences of linear operators acting on Banach space valued Fréchet differentiable functions to the unit operator, as well as other basic approximations including those under convexity ...
Anastassiou George A.
doaj +1 more source
RNA‐related functions of BRCA2 in transcription, replication, and genome stability
FEBS Letters, EarlyView.Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda +2 more
wiley +1 more source
Positive and Z-operators on Closed Convex Cones [PDF]
, 2018 Let $K$ be a closed convex cone with dual $\dual{K}$ in a finite-dimensional real Hilbert space. A \emph{positive operator} on $K$ is a linear operator $L$ such that $L\of{K} \subseteq K$.
Orlitzky, Michael
core +1 more source