Results 71 to 80 of about 830,215 (273)
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
ℐ-αβ-statistical relative uniform convergence for double sequences and its applications
Demonstratio MathematicaThis article introduces a novel concept of convergence, referred to as ℐ{\mathcal{ {\mathcal I} }}-αβ\alpha \beta -statistical relative uniform convergence, for double sequences of functions.
Bayram Nilay Sahin, Yıldız Sevda
doaj +1 more source
Positive solutions for a Hadamard-type fractional p-Laplacian integral boundary value problem
Nonlinear AnalysisIn this paper we study the existence of positive solutions to a Hadamard-type fractional integral boundary value problem using fixed point index.
Yihui Xu +3 more
doaj +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
On the modified beta approximating operators of first kind
Journal of Numerical Analysis and Approximation Theory, 2004 We define a general linear operator from which we obtain as special case the modified beta first kind operator\[(B_{p,q}f)(x)={B(p,q)}\int_0^1 t^{p-1}(1-t)^{q-1}f\left({B(p,q)}{B(p+a,q)}t^a x\right){\rm d}t.\]We consider here only the cases \(a=1\) and \
Vasile Miheşan
doaj +2 more sources
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
UN PROBLEMA TRIDIMENSIONALE DI TRASPORTO FUORI DI UNA SFERA RIFLETTENTE
Ratio Mathematica, 1991 In this paper we study the linear monoenergetic Boltzmann equation in the space external to a sphere ofradius n> f} with specular refiectionboundary conditions- By means oftheory of linear positive operator semigroups in Banach spaces we Show that ...
L Bassi, P Gamba
doaj