Results 51 to 60 of about 585,417 (307)

DETECTABILITY OF LINEAR DISCRETE TIME LINEAR SYSTEMS DEFINED BY POSITIVE OPERATORS [PDF]

open access: yesFiabilitate şi Durabilitate, 2010
In this paper we extend the notion of detectability, introduced in [1] in connection with stochastic systems, to a more general class of linear discrete time systems defined by positive operators.
V.M. Ungureanu
doaj  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

Some properties of the linear positive operators (III)

open access: yesJournal of Numerical Analysis and Approximation Theory, 1974
Not available.
A. Lupaş
doaj   +2 more sources

Weakly Ordered A-Commutative Partial Groups of Linear Operators Densely Defined on Hilbert Space [PDF]

open access: yes, 2017
The notion of a generalized effect algebra is presented as a generalization of effect algebra for an algebraic description of the structure of the set of all positive linear operators densely defined on a Hilbert space with the usual sum of operators ...
Janda , Jirí
core  

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

On the Monotonicity of Positive Linear Operators

open access: yesJournal of Approximation Theory, 1998
The main result of this paper concerns positive linear approximation operators of the so-called Feller type \[ K_n(f,x): =Ef(T_{n,x}) =\int_I f(t)dG_{n,x} (t),\;n\in\mathbb{N}, \] where the random variable \(T_{n,x}\) is the arithmetic mean of identically distributed random variables \(X_{i,x}\), \(I=1, \dots, n\) taking values in an interval \(I\) and
KHAN M. K.   +2 more
openaire   +3 more sources

Next‐generation proteomics improves lung cancer risk prediction

open access: yesMolecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj   +4 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

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