Results 71 to 80 of about 8,449,626 (275)

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

open access: yesFEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana   +3 more
wiley   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

open access: yesFEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés   +2 more
wiley   +1 more source

\(A\)-statistical convergence for a class of positive linear operators

open access: yesJournal of Numerical Analysis and Approximation Theory, 2006
In this paper we introduce a sequence of positive linear operators defined on the space \(C[0,a ...
M. A. Özarslan, O. Duman, O. Doğru
doaj   +2 more sources

Multi-Composite Activated Neural Networks Treated as Positive Linear Operators

open access: yesMathematics
Multi-composite activated neural network operators can be understood as positive linear operators, allowing them to be analyzed using standard, established theory.
George A. Anastassiou
doaj   +1 more source

On differences of linear positive operators

open access: yesAnalysis and Mathematical Physics, 2018
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Ali Aral, Daniela Inoan, Ioan Raşa
openaire   +3 more sources

A Theorem of Rolewicz's Type for Measurable Evolution Families in Banach Spaces [PDF]

open access: yes, 2001
Let $varphi$ be a positive and non-decreasing function defined on the real half-line and ${mathcal U}$ be a strongly measurable, exponentially bounded evolution family of bounded linear operators acting on a Banach space and satisfing a certain ...
Constantin Buse   +3 more
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Approximating Derivatives by a Class of Positive Linear Operators

open access: yesInternational Journal of Analysis and Applications, 2013
Some Direct Theorems for the linear combinations of a new class of positive linear operators have been obtained for both, pointwise and uniform simultaneous approximations.
Bramha Dutta Pandey, B. Kunwar
doaj   +2 more sources

Preservers for the p-Norm of Linear Combinations of Positive Operators

open access: yesAbstract and Applied Analysis, 2014
We describe the structure of those transformations on certain sets of positive operators which preserve the p-norm of linear combinations with given nonzero real coefficients. These sets are the collection of all positive pth Schatten-class operators and
Gergő Nagy
doaj   +1 more source

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