Results 151 to 160 of about 1,632,588 (354)

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

WORK ETHIC OF MALAYSIAN CIVIL SERVANTS [PDF]

This paper seeks to explore work ethic of Malaysian civil servants. Positive work ethic among others emphasize on hard work, commitment and dedication, and avoidance of wealth accumulation through unethical methods.
Abdul Rahman Abdul Rahim, Alwi Bin Shabuddin, Munira Mazlan, Othman Mohd. Yunus   +3 more
core  

Pengaruh Moral Karyawan dan Komitmen Organisasi terhadap Organizational Citizenship Behavior [PDF]

, 2016
This study aimed to determine the effect of employee morale and organizational commitment on organizational citizenship behavior, and determine the influence of employee morale and organizational commitment together to organizational citizenship behavior.
Suana, I. W. (I), Sucahya, I. W. (I)
core   +1 more source

Real‐World Investigation of Satralizumab in Patients With Neuromyelitis Optica Spectrum Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Satralizumab, a monoclonal antibody targeting the interleukin‐6 receptor, has demonstrated efficacy in clinical trials for neuromyelitis optica spectrum disorder (NMOSD). However, its real‐world effectiveness and safety compared to conventional immunosuppressive therapies remain uncertain.
Li‐Tsung Lin, Hui‐An Lin, Sheng‐Feng Lin   +2 more
wiley   +1 more source

Antecedent of Organizational Citizenship Behavior: Positive and Negative Affectivity [PDF]

Proceedings of the First International Conference of Economics, Business & Entrepreneurship, ICEBE 2020, 1st October 2020, Tangerang, Indonesia, 2021
Keumala Hayati, Indra Caniago
openaire   +1 more source

PENGARUH KEPUASAN KERJA TERHADAP ORGANIZATIONAL CITIZENSHIP BEHAVIOR (OCB) DENGAN KOMITMEN ORGANISASI SEBAGAI VARIABEL INTERVENING (Studi Pada Q Hotel Sangatta) [PDF]

This research aims to determine the effect of job satisfaction on organizational citizenship behavior with organizational commitment as an intervening variable. The location of this research was conducted at the Q Hotel Sangatta.
Rezaldi, Adam
core  

Analisa Servant Leadership Terhadap Organizational Citizenship Behavior (Ocb) Melalui Kepuasan Kerja Karyawan Di Hotel Bumi Surabaya [PDF]

, 2017
Tujuan dari penelitian ini adalah untuk menganalisis pengaruh positif dan signifikan gaya kepemimpinan servant leadership terhadap kepuasan kerja karyawan dan OCB serta pengaruh kepuasan kerja karyawan terhadap OCB di Hotel Bumi Surabaya.
Admaja, S. (Sintya), Fanny, F. (Fanny)
core  

Changes in Immune‐Inflammation Status and Acute Ischemic Stroke Prognosis in Prospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Inflammation is a critical risk factor for poor outcomes in cerebral infarction. Prior studies focused primarily on baseline inflammation status, neglecting dynamic longitudinal changes. We try to investigate the association between immune‐inflammation status alterations and stroke prognosis, and evaluated three systemic biomarkers'
Songfang Chen, Wenting Huang, Yitian Liu, Xuan Chen, Buyu Ke, Qian Shen, Hanyu Cai, Jing Sun, Yan Li, Yungang Cao, Beilei Hu, Keyang Chen   +11 more
wiley   +1 more source