Results 101 to 110 of about 96,168 (247)

Global exponential stability of positive periodic solution of the n-species impulsive Gilpin–Ayala competition model with discrete and distributed time delays

Journal of Biological Dynamics, 2018
In this paper, we study the n-species impulsive Gilpin–Ayala competition model with discrete and distributed time delays. The existence of positive periodic solution is proved by employing the fixed point theorem on cones.
Kaihong Zhao
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Positive almost periodic solutions to integral equations with superlinear perturbations via a new fixed point theorem in cones

Electronic Journal of Differential Equations, 2017
In this article, we establish a new fixed point theorem for nonlinear operators with superlinear perturbations in partially ordered Banach spaces, Then we use the fixed point theorem to prove the existence of positive almost periodic solutions to ...
Jing-Yun Zhao, Hui-Sheng Ding, Gaston M. N'Guerekata   +2 more
doaj  

Global Asymptotic Behavior of a Nonautonomous Competitor-Competitor-Mutualist Model

Abstract and Applied Analysis, 2013
The global asymptotic behavior of a nonautonomous competitor-competitor-mutualist model is investigated, where all the coefficients are time-dependent and asymptotically approach periodic functions, respectively.
Shengmao Fu, Fei Qu
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Positive periodic solutions for a predator-prey model with time delays and impulsive effect

Electronic Journal of Differential Equations, 2008
In this article, a two-species predator-prey model with time delays and impulsive effect is investigated. By using Mawhin's continuation theorem of coincidence degree theory, sufficient conditions are obtained for the existence of positive periodic ...
Yongkun Li, Shan Gao
doaj  

On the Dynamics of the Recursive Sequence

Discrete Dynamics in Nature and Society, 2012
We investigate the boundedness character, the oscillatory, and the periodic character of positive solutions of the difference equation , where , , and the initial conditions are arbitrary positive numbers.
Mehmet Gümüş, Özkan Öcalan, Nilüfer B. Felah   +2 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source