Results 111 to 120 of about 8,509,903 (292)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Periodic solution and stationary distribution of a stochastic epidemic model with two different epidemics and different epidemiological frameworks

Electronic Journal of Differential Equations
In epidemiology, more than one infectious disease can pose a risk to the host population. This area of study has attracted researchers in recent times.
Shivam Kumar Mishra, Syed Abbas, Juan Jose Nieto   +2 more
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Existence of Periodic Solutions and Stability of Zero Solution of a Mathematical Model of Schistosomiasis

Journal of Applied Mathematics, 2014
A mathematical model on schistosomiasis governed by periodic differential equations with a time delay was studied. By discussing boundedness of the solutions of this model and construction of a monotonic sequence, the existence of positive periodic ...
Lin Li, Zhicheng Liu
doaj   +1 more source

Positive periodic solutions of singular systems

, 2010
The existence and multiplicity of positive periodic solutions for second order non-autonomous singular dynamical systems are established with superlinearity or sublinearity assumptions at infinity for an appropriately chosen parameter. Our results provide a unified treatment for the problem and significantly improve several results in the literature ...
openaire   +2 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Necessary and sufficient conditions for the existence of periodic solution to singular problems with impulses

Electronic Journal of Differential Equations, 2014
In this article we give a necessary sufficient conditions for the existence of periodic solutions to impulsive periodic solution for a singular differential equation. The proof is based on the variational method.
Juntao Sun, Jifeng Chu
doaj  

Positive periodic solution for p-Laplacian neutral Rayleigh equation with singularity of attractive type

Journal of Inequalities and Applications, 2018
In this paper, we consider a kind of p-Laplacian neutral Rayleigh equation with singularity of attractive type, (ϕp(u(t)−cu(t−δ))′)′+f(t,u′(t))+g(t,u(t))=e(t). $$\bigl(\phi_{p} \bigl(u(t)-cu(t-\delta) \bigr)' \bigr)'+f \bigl(t,u'(t) \bigr)+g \bigl(t, u(t)
Yun Xin, Hongmin Liu, Zhibo Cheng
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

On computing frequency-responses of periodic systems [PDF]

, 2006
We address the efficient and numerically reliable computation of frequency responses of discrete-time periodic systems by using structure exploiting ...
Varga, Andreas
core