Results 81 to 90 of about 96,168 (247)

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Periodicity of the Positive Solutions of a Fuzzy Max-Difference Equation

Abstract and Applied Analysis, 2014
We investigate the periodic nature of the positive solutions of the fuzzy max-difference equation xn+1=maxAn/xn-m,xn-k,n=0,1,…, where k,m∈{1,2,…}, An is a periodic sequence of fuzzy numbers, and x-d,x-d+1,…,x0 are positive fuzzy numbers with d=m,k.
Qiuli He, Chunyan Tao, Taixiang Sun, Xinhe Liu, Dongwei Su   +4 more
doaj   +1 more source

Periodic solutions for an impulsive semi-ratio-dependent predator-prey model with patches and time delays

Electronic Journal of Qualitative Theory of Differential Equations, 2015
In this paper, we study the existence of a positive periodic solution for a two-species semi-ratio-dependent predator-prey system with time delays and impulses in a two-patch environment. By using the method of coincidence degree theorem, a set of easily
Ruixi Liang
doaj   +1 more source

Positive Periodic Solutions of Second‐Order Differential Equations with Delays [PDF]

Abstract and Applied Analysis, 2012
The existence results of positive ω‐periodic solutions are obtained for the second‐order differential equation with delays −u″ + a(t) = f(t, u(t − τ1), …, u(t − τn)), where a ∈ C(ℝ, (0, ∞)) is a ω‐periodic function, f : ℝ × [0, ∞) n → [0, ∞) is a continuous function, which is ω‐periodic in t, and τ1, τ2, …, τn are positive constants.
openaire   +4 more sources

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

On the Uniqueness and Dependence of Positive Periodic Solutions for Delay Differential Systems with Feedback Control

International Journal of Mathematics and Mathematical Sciences, 2012
This paper investigates a class of delay differential systems with feedback control. Sufficient conditions are obtained for the existence and uniqueness of the positive periodic solution by utilizing some results from the mixed monotone operator theory ...
Haitao Li, Yansheng Liu
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Periodic solution and stationary distribution of a stochastic epidemic model with two different epidemics and different epidemiological frameworks

Electronic Journal of Differential Equations
In epidemiology, more than one infectious disease can pose a risk to the host population. This area of study has attracted researchers in recent times.
Shivam Kumar Mishra, Syed Abbas, Juan Jose Nieto   +2 more
doaj  

The Dynamics of a Predator-Prey System with State-Dependent Feedback Control

Abstract and Applied Analysis, 2012
A Lotka-Volterra-type predator-prey system with state-dependent feedback control is investigated in both theoretical and numerical ways. Using the Poincaré map and the analogue of the Poincaré criterion, the sufficient conditions for the existence and ...
Hunki Baek
doaj   +1 more source