Results 161 to 170 of about 3,799,305 (383)

How can we increase the positive predictive value of PIRADS 4 and 5 lesions at mp-MRI? Development of a novel prediction tool relying on a large, multi-institutional series

, 2020
F. Barletta, A. Stabile, R.J. Karnes, Giovanni Motterle, N. Fossati, G. Gandaglia, F. Pellegrino, S. Scuderi, L. Nocera, E. Zaffuto, F. Scalvi, A. Rizzo, D. Cannoletta, Antonio Gallina, M. Menan, A. Pellegrino, E. Mazzone, M. Bandini, C.A. Bravi, V. Cucchiara, G. Brambilla, A. Esposito, F. Montorsi, F. De Cobelli, A. Briganti   +24 more
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Positive predictive value and impact of misdiagnosis of a heart failure diagnosis in administrative registers among patients admitted to a University Hospital cardiac care unit

Clinical Epidemiology, 2010
Shan Mard, Finn Erland NielsenDepartment of Cardiology, Herlev University Hospital, DenmarkObjective: To evaluate the positive predictive value (PPV) of a diagnosis of heart failure (HF) in the Danish National Registry of Patients (NRP) among patients ...
Shan Mard, Finn Erl, Nielsen
doaj  

Positive Predictive Values of Skin Prick Test Wheal Size for Egg and Peanut Allergy by Statistically Combining Data from Clinic and Population-based Samples of 12 Month Old Infants [PDF]

, 2009
Lyle C. Gurrin, Nicholas J. Osborne, Jennifer J. Koplin, Nadine A. Bertalli, Mimi L.K. Tang, Rebecca Werther, Katrina J. Allen   +6 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Automated Identification of Unhealthy Drinking Using Routinely Collected Data: A Machine Learning Approach [PDF]

, 2019
Background: Unhealthy drinking is prevalent in the United States and can lead to serious health and social consequences, yet it is under-diagnosed and under-treated. Identifying unhealthy drinkers can be time-consuming for primary care providers.
Bonnell, Levi N., Littenberg, Benjamin, Rose, Gail L., Wshah, Safwan R.   +3 more
core   +1 more source

Antibody Titer Has Positive Predictive Value for Vaccine Protection against Challenge with Natural Antigenic-Drift Variants of H5N1 High-Pathogenicity Avian Influenza Viruses from Indonesia [PDF]

, 2015
David E. Swayne, David L. Suarez, Erica Spackman, Samadhan Jadhao, Gwenae͏̈lle Dauphin, Mia Kim-Torchetti, James McGrane, J. Todd Weaver, Peter T. Daniels, Frank Wong, Paul Selleck, Agus Wiyono, Risa Indriani, Yuni Yupiana, Elly Sawitri Siregar, Teguh Y. Prajitno, Derek J. Smith, Ron A. M. Fouchier   +17 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Positive Predictive Value of Suspicious Findings in Standard Mammography according to Local Compression Mammography Results

مجله دانشکده پزشکی اصفهان, 2012
Background: By evaluating 47 performed standard mammographies, we found four pathologies including mass, calcification, asymmetric density, and distortion.
Atoosa Adibi, Marjan Emadi
doaj  

Positive Predictive Value for Multitarget Stool DNA After Bariatric and Metabolic Surgery. [PDF]

Gastro Hep Adv, 2023
Ebner DW, Burger KN, Broderick B, Mahoney DW, Kellogg TA, Acosta A, Kisiel JB.   +6 more
europepmc   +1 more source