Results 161 to 170 of about 791,044 (254)

Reply to Letter to the Editor: "Importance of Pretest Probability for Calculating Positive Predictive Value". [PDF]

Anatol J Cardiol
Erol S, Gürün Kaya A, Arslan F, Ayöz S, Gürsoy Çoruh A, Kul M, Özçınar E, Çiledağ A, Önen ZP, Kaya A, Özdemir Kumbasar Ö, Konstantinides SV.   +11 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Paucibacillary Tuberculosis Drives the Low Positive Predictive Value of Xpert MTB/RIF Ultra for Rifampicin Resistance Detection in Low-Prevalence Settings. [PDF]

Clin Infect Dis
Cuella-Martin I, Hakizayezu F, Ahmed A, Runyambo D, Niyompano H, Keysers J, De Rijk WB, Mulders W, Mitchell EMH, Decroo T, Habimana YM, Migambi P, Muvunyi CM, de Jong BC, Rigouts L, Ngabonziza JCS.   +15 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Positive predictive value of cervical cancer screening results recommended for colposcopy by human papillomavirus vaccination status at 3 U.S. healthcare systems. [PDF]

Cancer Causes Control
Pocobelli G, Lykken J, Haas JS, Tiro J, Doria-Rose VP, Hyun N, Silver MI, Kamineni A, Chubak J.   +8 more
europepmc   +1 more source

Positive Predictive Value of Diagnostic Test [PDF]

, 2020
openaire   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Stool-based methylated syndecan-2 testing has a high positive predictive value in an average/increased-risk population: a multicenter retrospective study. [PDF]

Gastroenterol Rep (Oxf)
Huang X, Zhang S, Liu Y, Sui X, Pan P, Zhao Y, Fang Q, Cai Y, Gong Y, Li W, Lan H, Deng Y, Xu Y, Cai Z, Chen H, Huang S, Zhou Q, Huang Z, Feng B, Li Y, Yin W, Li Z, He X, Zhao S, Bai Y.   +24 more
europepmc   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Evaluating the positive predictive value of code-based identification of cirrhosis and its complications utilizing GPT-4. [PDF]

Hepatology
Far AT, Far AT, Bastani A, Lee A, Gologorskaya O, Huang CY, Pletcher MJ, Lai JC, Ge J.   +8 more
europepmc   +1 more source