Results 111 to 120 of about 7,520,155 (290)

Targeting the YAP‐BST2 Axis Overcomes Intrinsic Anti‐PD‐1 Resistance in Metastatic Gastric Cancer

Advanced Science, EarlyView.
Concurrent YAP hyperactivation and Tp53 loss in Atp4b‐expressed parietal cell lineage drives gastric cancer initiation, multi‐organ metastasis, and intrinsic resistance to anti‐PD‐1 therapy. BST2 emerges as a direct YAP‐TEAD transcriptional target that engages PIRA2 on myeloid cells to establish an immunosuppressive microenvironment.
Weihong Zhang, Shilong Wang, Meng Wang, Ruixian Yu, Jingwu Yue, Lin Shao, Hui Zhang, Mengwen Zhu, Luyang Tian, Shuting Cheng, Weimin Qin, Yang Tang, Yi Han, Wenjia Wang, Liwei An, Yan Meng, Shi Jiao, Zhaocai Zhou   +17 more
wiley   +1 more source

Post-Obstructive Pulmonary Edema: A Different Type of Pulmonary Edema

Amrita Journal of Medicine
Post-obstructive pulmonary edema (POPE) or negative pressure pulmonary edema is a unique clinical entity occurring in the context of airway obstruction. Two distinct subclasses of POPE have been described in literature: type I occurring in the setting of
Srikant K. Malegaonkar
doaj   +1 more source

Cross‐scale Material‐Structure Synergy for 2D Metamaterials: Toward Customizable Intelligent Electromagnetic Manipulation in Multiphysics Fields

Advanced Science, EarlyView.
Recent advances in metasurface‐enabled low‐observable technologies are reviewed from the perspective of cross‐scale material–structure synergy. Electromagnetic, thermal, optical, and acoustic stealth are highlighted together with dynamic tuning, programmable coding, data‐driven inverse design, artificial intelligence, multispectral compatibility, and ...
Shuhao Wang, Xing Yang, Liping Liu, Yang Peng, Yangyang Wang, Hualiang Lv   +5 more
wiley   +1 more source

Multimodal Imaging of Hypoxia, Metabolism and pH in Feline Sarcoma Using Hyperpolarized 13C MRI and PET

Advanced Science, EarlyView.
This work presents a clinically deployable simultaneous PET/MRI workflow which integrates hyperpolarized 13C imaging of metabolism and extracellular pH with [18F]FMISO PET to characterize hypoxia, acidosis, and metabolic reprogramming in feline sarcoma.
Martin Grashei, Tanja Groll, Stephanie Kahl, Silke Baer, Elisabeth Bliemsrieder, Frits H. A. van Heijster, Andre Wendlinger, Pascal Wodtke, Jorge Cabello, Susan Notohamiprodjo, Christian Lohrmann, Markus Schwaiger, Wolfgang A. Weber, Katja Steiger, Andrea Meyer‐Lindenberg, Johannes Hirschberger, Christine Baumgartner, Franz Schilling   +17 more
wiley   +1 more source

Risk factor analysis and development of a risk prediction model for facial pressure injury associated with noninvasive positive pressure ventilation in patients with chronic obstructive pulmonary disease based on symptom science theory

Frontiers in Medicine
BackgroundNoninvasive positive pressure ventilation is a key treatment for acute exacerbations of chronic obstructive pulmonary disease and is associated with a facial pressure injury incidence of 20% to 30%. However, current risk assessment still relies
Chen Cheng, Lulu Cui, Changhai Wang, Yujie Zhang, Jun Ge, Jinmei Peng, Bin Zhang, Rong Zhao, Duoduo Qiao, Xiaoyun Chen, Yaojun Zhang, Pei Zhang, Manhong Zhang, Yan Wang, Xuling Gao, Changchun Song, Qiankun Liu   +16 more
doaj   +1 more source

Isocyanate‐Modified Melatplatin(IV) Enhances Antitumor Efficacy via TCF4/COL6A3‐Mediated Extracellular Matrix Remodeling and cGAS‐STING Pathway Activation in Bladder Cancer

Advanced Science, EarlyView.
A series of melatonin‐conjugated platinum(IV) prodrugs was functionalized with isocyanate chains (compounds 5‒12). MP‐12C (compound 11) was identified as the lead candidate, with optimal potency and safety. MP‐12C exhibited greater efficacy than cisplatin by increasing intracellular uptake, reshaping the extracellular matrix, activating the cGAS‐STING ...
Linhui Wang, Xiaomeng Liu, Tao Zhu, Zirun Su, Ruiping Liu, Zhe Li, Kaixuan Du, Kaipeng Jia, Chong Fu, Yuda Lin, Zihan Xue, Zhe Zhang, Chong Shen, Yunkai Qie, Zhouliang Wu, Zhiheng Liu, Kangkang Liu, Jingyuan Xu, Hailong Hu   +18 more
wiley   +1 more source

Efficacy of long-term noninvasive positive pressure ventilation in stable hypercapnic COPD patients with respiratory failure: a meta-analysis of randomized controlled trials

, 2017
Hao Liao,* Wendi Pei,* Hongfu Li,* Yuwen Luo, Kai Wang, Rui Li, Limei Xu, Xin Chen Department of Respiratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, People’s Republic of China *These authors contributed equally to ...
Xu L, Li H, Liao H, Luo Y, Li R, Chen X, Pei W, Wang K   +7 more
core  

Smartphone‐Guided Visible Light Modulation of RSNOs for Antimicrobial Activity via Controlled Nitric Oxide Release

Advanced Science, EarlyView.
A light‐activated catheter insert combines antimicrobial blue light with nitric oxide release to generate complementary oxidative and nitrosative stress, producing potent broad‐spectrum antimicrobial activity. The approach achieves greater than 4‐log reductions in bacterial and fungal viability and significantly reduces Staphylococcus aureus ...
Alexander Bruckmann, Adam Brooks Goodman, Myddelton C. Parker, Mark Garren, Ji Eun Park, Chad Schmiedt, Hitesh Handa, Elizabeth J. Brisbois   +7 more
wiley   +1 more source

Solar induced ventilation in the Algerian and similar climates [PDF]

, 1989
In hot climates ventilation can be a useful means of cooling dwellings, if the outside air be cooler than that inside the dwelling. Often, in hot regions the outside air is so hot during the day that cooling by ventilation is of no benefit until the ...
Bouchair, Ammar
core   +1 more source

Improvement of summer comfort by passive cooling with increased ventilation and night cooling [PDF]

, 2013
The study describes the potential improvement of summer comfort and reduction of energy consumption that can be achieved by adopting passive cooling solutions, such as daytime comfort ventilation with increased air velocities and night cooling, in ...
Pellegrini, Tommaso
core