British Journal of Clinical Pharmacology, EarlyView.Introduction In recent years, the treatment of spinal muscular atrophy (SMA), a rare disease, has significantly progressed, improving patients' survival and overall quality of life. However, current SMA treatments are expensive, and some (nusinersen) are very inconvenient for patients.
Andrej Belančić +4 more
wiley +1 more source
The emergence of the "baby lung": a mechanical consequence of positive pressure ventilation and reduced pulmonary compliance. [PDF]
J Thorac Disvan Egmond J, Kristensen MS, Mulier JP.
europepmc +1 more source
Non-invasive positive pressure ventilation for severe thoracic trauma [PDF]
, 2000 Mark Garfield, Richard Howard-Griffin
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Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics
British Journal of Clinical Pharmacology, EarlyView.Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay +5 more
wiley +1 more source
Decreased Incidence of Post-Extubation Respiratory Failure in Very Low Birth Weight (VLBW) Infants: A Randomized Trial of Nasopharyngeal Synchronized Intermittent Mandatory Ventilation (NP-SIMV) Versus Nasopharyngeal Continuous Positive Airway Pressure (NP-CPAP) [PDF]
, 1999 Philippe Friedlich +5 more
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Intravenous lanadelumab for the treatment of moderately ill COVID‐19 patients
British Journal of Clinical Pharmacology, EarlyView.Aims Kallikrein‐kinin system (KKS) dysregulation is hypothesized to play a pathogenetic role in COVID‐19‐associated pulmonary oedema. To investigate the efficacy and safety of intravenous lanadelumab, a monoclonal antibody that inhibits plasma kallikrein, in COVID‐19, we conducted a phase 2, open‐label, randomized‐controlled, proof‐of‐concept ...
Job J. Engel +12 more
wiley +1 more source
Chloramine/Chlorine Injury Treated with Noninvasive Positive Pressure Ventilation: A Report of Two Cases. [PDF]
Clin Pract Cases Emerg MedFisher R +5 more
europepmc +1 more source
PS-226 Effects Of Different Ventilation Rate (vr) Targets In A Model Of Neonatal Manual Positive Pressure Ventilation (ppv): Abstract PS-226 Table 1 [PDF]
, 2014 C Cocucci, Leonor Acha, Gabriel Musante
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British Journal of Clinical Pharmacology, EarlyView.While providing potentially life‐saving cardiorespiratory support for critically ill patients, extracorporeal membrane oxygenation (ECMO) may detrimentally affect pharmacokinetic (PK) performance and concurrent drug efficacy and safety. We describe a patient with Pneumocystis jirovecii pneumonia (PJP) in the context of acquired immunodeficiency ...
Tom C. Zwart +7 more
wiley +1 more source