Results 91 to 100 of about 13,731,074 (335)
FEBS Letters, EarlyView.In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi +5 more
wiley +1 more source
FEBS Letters, EarlyView.Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu +17 more
wiley +1 more source
Positive periodic solutions for second-order neutral differential equations with functional delay
Electronic Journal of Differential Equations, 2012 We use Krasnoselskii's fixed point theorem to prove the existence of positive periodic solutions of the second-order nonlinear neutral differential equation $$ frac{d^2}{dt^2}x(t)+p(t)frac{d}{dt}x(t)+q(t)x(t) =cfrac{d}{dt}x(t-au(t))+f(t,h(x(t)),g(x ...
Ernest Yankson
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Positive Solution of a Nonlinear Fractional Differential Equation Involving Caputo Derivative
, 2012 This paper is concerned with a nonlinear fractional differential equation involving Caputo derivative. By constructing the upper and lower control functions of the nonlinear term without any monotone requirement and applying the method of upper and lower
Changyou Wang, Haiqiang Zhang, Shu Wang
semanticscholar +1 more source
FEBS Letters, EarlyView.Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria +3 more
wiley +1 more source
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source
Positive solutions for multipoint boundary-value problem with parameters
Electronic Journal of Differential Equations, 2008 In this paper, we study a generalized Sturm-Liouville boundary-value problems with two positive parameters. By constructing a completely continuous operator and combining fixed point index theorem and some properties of the eigenvalues of linear ...
Zhongli Wei, Juanjuan Xu
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, 2011 The method of upper and lower solutions and the Schauder fixed point theorem are used to investigate the existence and uniqueness of a positive solution to a singular boundary value problem for a class of nonlinear fractional differential equations with ...
Changyou Wang +3 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield +3 more
wiley +1 more source
Positive solutions of a boundary value problem with integral boundary conditions
Electronic Journal of Differential Equations, 2011 We consider boundary-value problems studied in a recent paper. We show that some existing theory developed by Webb and Infante applies to this problem and we use the known theory to show how to find improved estimates on parameters $mu^*, lambda ...
Jeff R. L. Webb
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