Results 161 to 170 of about 17,377,748 (367)

Principal solutions of positive linear Hamiltonian systems [PDF]

, 1976
Don Hinton
openalex   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Positive solutions for anisotropic discrete boundary-value problems

Electronic Journal of Differential Equations, 2013
Using mountain pass arguments and the Karsuh-Kuhn-Tucker Theorem, we prove the existence of at least two positive solution for anisotropic discrete Dirichlet boundary-value problems. Our results generalized and improve those in [16].
Marek Galewski, Szymon Glab, Renata Wieteska   +2 more
doaj  

Nonuniformly elliptic equations: Positivity of weak solutions [PDF]

, 1973
Charles V. Coffman, R. J. Duffin, Victor J. Mizel   +2 more
openalex   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Positive solutions of nonlinear elliptic equations—existence and nonexistence of solutions with radial symmetry in 𝐿_{𝑝}(𝑅^{𝑁}) [PDF]

, 1984
John Toland
openalex   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Existence and concentration of ground state solutions for a Kirchhoff type problem

Electronic Journal of Differential Equations, 2016
This article concerns the Kirchhoff type problem $$\displaylines{ -\Big(\varepsilon^2a+\varepsilon b\int_{\mathbb{R}^3} |\nabla u|^2dx\Big)\Delta u +V(x)u= K(x)|u|^{p-1}u,\quad x\in \mathbb{R}^3,\cr u\in H^1(\mathbb{R}^3), }$$ where a,b are ...
Haining Fan
doaj  

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Positive solutions for fractional differential equations with variable coefficients

Electronic Journal of Differential Equations, 2012
In this article, we study the existence of the positive solutions for a class of differential equations of fractional order with variable coefficients.
Yi Chen, Zhanmei Lv
doaj