Results 141 to 150 of about 5,799,011 (326)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Semilinear elliptic problems involving Hardy-Sobolev-Maz'ya potential and Hardy-Sobolev critical exponents

open access: yesElectronic Journal of Differential Equations, 2016
In this article, we study a class of semilinear elliptic equations involving Hardy-Sobolev critical exponents and Hardy-Sobolev-Maz'ya potential in a bounded domain. We obtain the existence of positive solutions using the Mountain Pass Lemma.
Rui-Ting Jiang, Chun-Lei Tang
doaj  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Varying domains in a general class of sublinear elliptic problems

open access: yesElectronic Journal of Differential Equations, 2004
In this paper we use the linear theory developed in [8] and [9] to show the continuous dependence of the positive solutions of a general class of sublinear elliptic boundary value problems of mixed type with respect to the underlying domain.
Santiago Cano-Casanova   +1 more
doaj  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Positive solutions for a 2nth-order p-Laplacian boundary value problem involving all derivatives

open access: yesElectronic Journal of Differential Equations, 2013
In this work, we are mainly concerned with the positive solutions for the 2nth-order p-Laplacian boundary-value problem $$displaylines{ -(((-1)^{n-1}x^{(2n-1)})^{p-1})' =f(t,x,x',ldots,(-1)^{n-1}x^{(2n-2)},(-1)^{n-1}x^{(2n-1)}),cr x^{(2i)}(0)=x ...
Youzheng Ding, Jiafa Xu, Xiaoyan Zhang
doaj  

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