Results 131 to 140 of about 5,799,011 (326)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Dirichlet problem for a second order singular differential equation

open access: yesElectronic Journal of Differential Equations, 2006
This article concerns the existence of positive solutions to the Dirichlet problem for a second order singular differential equation. To prove existence, we use the classical method of elliptic regularization.
Wenshu Zhou
doaj  

Positive solutions of viscoelastic problems

open access: yes, 2009
23 pp, 2 ...
Seredynska, Malgorzata, Hanyga, Andrzej
openaire   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Existence of solutions to nonlinear fractional Schrodinger equations with singular potentials

open access: yesElectronic Journal of Differential Equations, 2016
We study the eigenvalue problem $$ (-\Delta)^s u(x)+ V(x)u(x)-K(x)|u|^{p-2}u(x) =\lambda u(x) \quad \text{in } \mathbb{R}^N, $$ where $s\in(0,1)$, $N>2s ...
Qingxuan Wang, Dun Zhao, Kai Wang
doaj  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

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