Results 121 to 130 of about 10,534,085 (253)
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Solution-focused model for improving individual university teaching
, 2003 Universities commonly use individual teaching development as one of a suite of strategies to improve teaching and learning outcomes. This paper outlines an individual teaching development programme based on the tenets of solution-focused brief therapy ...
M Devlin (9896822)
core
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Electronic Journal of Differential Equations, 2006 By constructing some special cones and using fixed point theorem of cone expansion and compression, this paper presents some necessary and sufficient conditions for the existence of $C^{4n-2}$ positive solutions to a class of singular boundary-value
Chenglong Zhao +2 more
doaj
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Three positive solutions for a system of singular generalized Lidstone problems
Electronic Journal of Differential Equations, 2009 In this article, we show the existence of at least three positive solutions for the system of singular generalized Lidstone boundary value problems $displaylines{ (-1)^m x^{(2m)}=a(t)f_1(t,x,-x'',dots,(-1)^{m-1}x^{(2m-2)},y,-y'',cr dots,(-1)^{n-1}y^{
Jiafa Xu, Zhilin Yang
doaj
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Nonlinear Analysis, 2012 This paper is concerned with the mixed boundary value problem of the second order singular ordinary differential equation [Φ(ρ(t)x 0 (t))]0 + f(t, x(t), x0 (t)) = 0, t ∈ R, limt→−∞ x(t) = R +∞ −∞ g(s, x(s), x0 (s)) ds, limt→+∞ ρ(t)x 0 (t) = R +∞
Yuji Yuji
doaj
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source