Results 121 to 130 of about 2,039,640 (315)
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Electronic Journal of Differential Equations, 2019 This article studies the existence and multiplicity of component-wise positive solutions for systems of nonlinear Hammerstein integral equations. In this system one nonlinear term is uniformly superlinear or uniformly sublinear, and the other is ...
Xiyou Cheng, Zhaosheng Feng
doaj
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Solution-focused model for improving individual university teaching
, 2003 Universities commonly use individual teaching development as one of a suite of strategies to improve teaching and learning outcomes. This paper outlines an individual teaching development programme based on the tenets of solution-focused brief therapy ...
M Devlin (9896822)
core
Positive Solution to a Nonlinear Elliptic Problem
Potential Analysis, 2016 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Existence of positive solutions for higher order singular sublinear elliptic equations
Electronic Journal of Differential Equations, 2006 We present existence result for the polyharmonic nonlinear problem $$displaylines{ (-Delta )^{pm} u=varphi (.,u)+psi (.,u),quad hbox{in }B cr u>0,quad hbox{in }B cr lim_{|x|o 1} frac{(-Delta )^{jm}u(x)}{(1-|x|)^{m-1}}=0, quad 0leq jleq p-1,
Imed Bachar
doaj
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Uniform estimates for positive solutions of a class of semilinear elliptic equations and related Liouville and one-dimensional symmetry results [PDF]
, 2013 We consider the semilinear elliptic equation $\Delta u = W'(u)$ with Dirichlet boundary conditions in a smooth, possibly unbounded, domain $\Omega \subset \mathbb{R}^n$. Under suitable assumptions on the potential $W$, including the double well potential
Sourdis, Christos
core
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source