Results 171 to 180 of about 17,909,648 (352)

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

open access: yesMolecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard   +12 more
wiley   +1 more source

Existence of multiple solutions for quasilinear elliptic equations in R^N

open access: yesElectronic Journal of Differential Equations, 2014
In this article, we establish the multiplicity of positive weak solution for the quasilinear elliptic equation $$\displaylines{ -\Delta_p u+\lambda|u|^{p-2}u=f(x) |u|^{s-2 }u+h(x)|u|^{r-2}u\quad x\in \mathbb{R}^N,\cr u>0\quad x\in \mathbb{R}^N ...
Honghui Yin, Zuodong Yang
doaj  

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard   +5 more
wiley   +1 more source

Positive solutions for second-order m-point boundary-value problems with nonlinearity depending on the first derivative

open access: yesElectronic Journal of Differential Equations, 2006
We consider multiplicity of positive solutions for second-order m-point boundary-value problems, with the first order derivative involved in the nonlinear term. Using a fixed point theorem, we show the existence of at least three positive solutions.
Liu Yang, Xiping Liu, Chunfang Shen
doaj  

Screening for lung cancer: A systematic review of overdiagnosis and its implications

open access: yesMolecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz   +12 more
wiley   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

open access: yesMolecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece   +18 more
wiley   +1 more source

Existence of positive solutions to three-point phi-Laplacian BVPs via homotopic deformations

open access: yesElectronic Journal of Differential Equations, 2012
Under suitable conditions and via homotopic deformation, we provide existence results for a positive solution to the three-point $phi$-Laplacian boundary-value problem $$displaylines{ -( aphi(u'))'(x)=b(x) f(x,u(x)),quad xin ( 0,1), cr u(0)=alpha u ...
Nadir Benkaci   +2 more
doaj  

Home - About - Disclaimer - Privacy