Results 181 to 190 of about 17,377,748 (367)

Multiple positive solutions for a third-order three-point BVP with sign-changing Green's function

open access: yesElectronic Journal of Differential Equations, 2012
This article concerns the third-order three-point boundary-value problem $$displaylines{ u'''(t)=f(t,u(t)),quad tin [0,1], cr u'(0)=u(1)=u''(eta)=0. }$$ Although the corresponding Green's function is sign-changing, we still obtain the existence of
Jian-Ping Sun, Juan Zhao
doaj  

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

open access: yesMolecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma   +9 more
wiley   +1 more source

A necessary and sufficient condition for the existence of positive solutions to singular boundary-value problems of higher order differential equations

open access: yesElectronic Journal of Differential Equations, 2006
By constructing some special cones and using fixed point theorem of cone expansion and compression, this paper presents some necessary and sufficient conditions for the existence of $C^{4n-2}$ positive solutions to a class of singular boundary-value
Chenglong Zhao   +2 more
doaj  

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

open access: yesMolecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu   +12 more
wiley   +1 more source

Landscape of BRAF transcript variants in human cancer

open access: yesMolecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda   +5 more
wiley   +1 more source

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