Results 281 to 290 of about 13,879,944 (380)

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

A statistical estimation of fractional order cryptosporidiosis epidemic model. [PDF]

Sci Rep
Ahmed N, Alhilfi WA, AlMansury HAZ, Elwahab MEA, Tahir M, Alqasem OA, Iqbal Z, Raza A, Ceesay B, Rafiq M, Khan I.   +10 more
europepmc   +1 more source

Existence de deux solutions positives pour un problème elliptique à paramètre dans $\mathbb R^n$

, 1994
Alice Simon, Peter Volkmann
openalex   +2 more sources

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Successful stimulation of myocardial ganglionic plexi by Tau-20 in the absence of cardiac damage. [PDF]

Front Physiol
Li S, Kay JA, Agha-Jaffar D, Gao CSY, Perkins J, Koutsoftidis S, Drakakis EM, Cantwell CD, Wang L, Kanagaratnam P, Chowdhury RA.   +10 more
europepmc   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Verifying Proper Function of the Aerosol Evacuation System Prior to Sorting Potentially Infectious Samples. [PDF]

Curr Protoc
Reifel KM, Aspland A, Dervish S, Douagi I, Fears AC, Jellison ER, Midkiff CC, Mockus-Daehn T, Moström MJ, Solga M, Swan BK, Thomas J, Perfetto S.   +12 more
europepmc   +1 more source

Multiple Positive Solutions of Some Boundary Value Problems

, 1994
Lynn Erbe, S.C. Hu, Haiyan Wang
openalex   +1 more source