Ubiquitination of transcription factors in cancer: unveiling therapeutic potential
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley +1 more source
A Novel Optimized Silver Nitrate Staining Method for Visualizing and Quantifying the Osteocyte Lacuno-Canalicular System (LCS). [PDF]
Wu J+7 more
europepmc +1 more source
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen+12 more
wiley +1 more source
Extending the interval for changing flushing solutions for central venous and arterial line systems in the intensive care unit: An evidence-based quality improvement project. [PDF]
Padigos J+4 more
europepmc +1 more source
Does Porphyromonas gingivalis truly inhibit the oral carcinogenesis?
Chen‐xi Li, Zhong‐cheng Gong
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A comparative study of deterministic and stochastic computational modeling approaches for analyzing and optimizing COVID-19 control. [PDF]
Kadri A+5 more
europepmc +1 more source
Multiple Positive Solutions of Impulsive Nonlinear Fredholm Integral Equations and Applications
D.J. Guo
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Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova+18 more
wiley +1 more source
The nonlinear fast diffusion equation on smooth metric measure spaces: Hamilton-Souplet-Zhang estimates and a Ricci-Perelman super flow. [PDF]
Taheri A, Vahidifar V.
europepmc +1 more source