Results 121 to 130 of about 15,510,191 (369)

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

open access: yesMolecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin   +14 more
wiley   +1 more source

Nonexistence of radial positive solutions for a nonpositone system in an annulus

open access: yesElectronic Journal of Differential Equations, 2011
In this article we study the nonexistence of radial positive solutions for a nonpositone system in an annulus by using energy analysis and comparison methods.
Said Hakimi
doaj  

Positive Solutions for a Hadamard Fractional p-Laplacian Three-Point Boundary Value Problem

open access: yesMathematics, 2019
This article is to study a three-point boundary value problem of Hadamard fractional p-Laplacian differential equation. When our nonlinearity grows ( p − 1 ) -superlinearly and ( p − 1 ) -sublinearly, the existence of positive ...
Jiqiang Jiang   +3 more
doaj   +1 more source

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

open access: yesMolecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane   +16 more
wiley   +1 more source

Positive solutions and global bifurcation of strongly coupled elliptic systems

open access: yesElectronic Journal of Differential Equations, 2013
In this article, we study the existence of positive solutions for the coupled elliptic system egin{gather*} -Delta u= lambda (f(u, v)+ h_{1}(x) ) quad ext{in }Omega, \ -Delta v= lambda (g(u, v)+ h_{2}(x))quad ext{in }Omega, \ u =v=0 quad ext{on ...
Jagmohan Tyagi
doaj  

Nonexistence of positive solutions for a system of coupled fractional boundary value problems

open access: yes, 2015
We investigate the nonexistence of positive solutions for a system of nonlinear Riemann-Liouville fractional differential equations with coupled integral boundary conditions.
J. Henderson, R. Luca
semanticscholar   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

open access: yesMolecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park   +6 more
wiley   +1 more source

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