Results 131 to 140 of about 8,405,278 (297)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Positive Solutions of an Emden-Fowler Equation
Journal of Mathematical Analysis and Applications, 1994 Some new results concerning asymptotic integration and global existence of positive solutions of the Emden-Fowler equation \((r(t)x')' = P(t) | x |^{\nu-1} x\) are given. These results improve well known results of this area. Some applications to certain elliptic problems are given, too.
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FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Systems of nonlinear algebraic equations with positive solutions. [PDF]
J Inequal Appl, 2017 Ciurte A, Nedevschi S, Rasa I.
europepmc +1 more source
Positive solutions to sublinear elliptic problems
Colloquium Mathematicum, 2019 Let $L$ be a second order elliptic operator $L$ with smooth coefficients defined on a domain $Ω$ in $\mathbb{R}^d $, $d\geq3$, such that $L1\leq 0$. We study existence and properties of continuous solutions to the following problem \begin{equation}\label{00} Lu=φ(\cdot,u),% & \hbox{in $Ω$; in the sens of distribution;} \\ \end{equation} in $Ω ...
openaire +3 more sources
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Bifurcation of positive solutions for a semilinear equation with critical Sobolev exponent
Electronic Journal of Differential Equations, 2006 In this note we consider bifurcation of positive solutions to the semilinear elliptic boundary-value problem with critical Sobolev exponent $$displaylines{ -Delta u = lambda u - alpha u^p+ u^{2^*-1}, quad u >0 , quad hbox{in } Omega,cr u=0, quad hbox ...
Yuanji Cheng
doaj
An existence result for $(p,q)$-Laplacian BVP with falling zeros.
Electronic Journal of Qualitative Theory of Differential EquationsWe show the existence of a positive solution to the $(p,q)$-Laplacian problem \begin{equation*} \begin{cases} -\Delta _{p}u-a\Delta _{q}u=\lambda f(u)-h(x)\quad \text{in }\Omega, \\ u=0\quad \text{on }\partial \Omega, \end{cases} \end{equation*} for ...
Bandar Alreshidi, Dang Dinh Hai
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