Results 121 to 130 of about 8,405,278 (297)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Decaying positive solutions of some quasilinear differential equations [PDF]
, 1998 summary:The existence of decaying positive solutions in ${\Bbb R}_+$ of the equations $(E_\lambda )$ and $(E_\lambda^1)$ displayed below is considered. From the existence of such solutions for the subhomogeneous cases (i.e.
Tadie
core +1 more source
Positive solutions for nonlinear Robin problems
Electronic Journal of Differential Equations, 2017 We consider a parametric Robin problem driven by the p-Laplacian with an indefinite potential and with a superlinear reaction term which does not satisfy the Ambrosetti-Rabinowitz condition. We look for positive solutions.
Diego Averna +2 more
doaj
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Positive solutions for nonlinear elliptic systems
Electronic Journal of Differential Equations, 2012 In this article, we study the existence of positive solutions for the system $$displaylines{ Delta u=H(x,u,v),cr Delta v=K(x,u,v),hbox{in }mathbb{R}^n; (ngeq 3), }$$ where $H,K: mathbb{R}^nimes[0,infty)imes[0,infty)o[0,infty)$ are continuous ...
Adel Ben Dekhil
doaj
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
CGIAR Initiative on Nature-Positive Solutions: Annual Technical Report 2022 [PDF]
, 2023 CGIAR Initiative on Nature-Positive Solutions
core +1 more source
Circle Solutions, a philosophy and pedagogy for learning positive relationships: What promotes and inhibits sustainable outcomes? [PDF]
, 2013 Educators are increasingly aware that the efficacy of social and emotional learning (SEL) is dependent on implementation factors, not just program content.
Sue Roffey +3 more
core +1 more source