Results 131 to 140 of about 3,840,200 (275)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Triple positive solutions for m-point boundary-value problems of dynamic equations on time scales with p-Laplacian

Electronic Journal of Differential Equations, 2015
In this article we study the existence of positive solutions for m-point dynamic equation on time scales with p-Laplacian. We prove that the boundary-value problem has at least three positive solutions by applying the five functionals fixed-point ...
Abdulkadir Dogan
doaj  

Multiple positive solutions to a coupled systems of nonlinear fractional differential equations. [PDF]

Springerplus, 2016
Shah K, Khan RA.
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Multiple positive solutions for nonlinear fractional boundary value problems. [PDF]

ScientificWorldJournal, 2013
Zhao D, Liu Y.
europepmc   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Positive solutions for generalized Hardy-Henon equations

Electronic Journal of Differential Equations
This article concerns a generalized Hardy-Henon equation and its associated Dirichlet problem. We obtain upper and lower estimates for positive solutions, and establish the existence and nonexistence of positive solutions to both the equation and its ...
Xizheng Zhang, Xiyou Cheng, Meihua Yang
doaj  

Existence and multiplicity of solutions for nonlocal elliptic problems

Electronic Journal of Differential Equations, 2013
This article concerns the existence and multiplicity solutions for a class of p-Kirchhoff type equations with Neumann boundary conditions. Our technical approach is based on variational methods.
Mohammed Massar
doaj  

Multiple positive solutions to nonlinear boundary value problems of a system for fractional differential equations. [PDF]

ScientificWorldJournal, 2014
Zhai C, Hao M.
europepmc   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source