Results 151 to 160 of about 3,779,631 (328)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Solutions to singular quasilinear elliptic equations on bounded domains

Electronic Journal of Differential Equations, 2018
In this article we study quasilinear elliptic equations with a singular operator and at critical Sobolev growth. We prove the existence of positive solutions.
Zhouxin Li, Youjun Wang
doaj  

Multiple positive solutions to a coupled systems of nonlinear fractional differential equations. [PDF]

Springerplus, 2016
Shah K, Khan RA.
europepmc   +1 more source

Positive strongly decreasing solutions of Emden-Fowler type second-order difference equations with regularly varying coefficients

, 2019
Aleksandra B. Kapešić, Jelena Manojlović   +1 more
openalex   +2 more sources

Position paper : solutions

, 2016
17 ...
openaire   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Multiple positive solutions for nonlinear fractional boundary value problems. [PDF]

ScientificWorldJournal, 2013
Zhao D, Liu Y.
europepmc   +1 more source

Multiplicity of positive solutions for Kirchhoff type problems with nonlinear boundary condition [PDF]

, 2019
Chun‐Yu Lei, Gao-Sheng Liu
openalex   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Positive solutions for generalized Hardy-Henon equations

Electronic Journal of Differential Equations
This article concerns a generalized Hardy-Henon equation and its associated Dirichlet problem. We obtain upper and lower estimates for positive solutions, and establish the existence and nonexistence of positive solutions to both the equation and its ...
Xizheng Zhang, Xiyou Cheng, Meihua Yang
doaj