Results 41 to 50 of about 87,152,843 (234)

Development of a population pharmacokinetic model using combined paediatric and adult data for four pulmonary arterial hypertension drugs

British Journal of Clinical Pharmacology, EarlyView.
Aims Pulmonary arterial hypertension (PAH) is a syndrome characterized by elevated pulmonary artery pressure. We developed a population pharmacokinetic (PPK) model using combined plasma drug concentration data from Japanese paediatric (<15 years) and adult (≥15 years) patients with PAH to investigate the pharmacokinetic characteristics of PAH ...
Motoyasu Miura, Shimako Tanaka, Ririka Aihara, Shun Yamamoto, Yasumi Nakashima, Yasuharu Kashiwagura, Akio Hakamata, Sachiko Miyakawa, Mariko Tatsuguchi, Keiichi Odagiri, Noriyuki Namiki, Naoki Inui, Hiroshi Watanabe, Shinya Uchida   +13 more
wiley   +1 more source

Integrable viscous conservation laws [PDF]

, 2015
We propose an extension of the Dubrovin-Zhang perturbative approach to the study of normal forms for non-Hamiltonian integrable scalar conservation laws. The explicit computation of the first few corrections leads to the conjecture that such normal forms
Moro, Antonio, Arsie, Alessandro, Lorenzoni, Paolo   +2 more
core   +1 more source

Optimization of 3D‐Printed Structured Packings—Current State and Future Developments

Chemie Ingenieur Technik, EarlyView.
This paper gives an overview about structured packing development for distillation, surveying heuristic development cycles, computational fluid dynamics simulations, and additive manufacturing techniques. The emerging application of shape optimization to improve packings is emphasized, and its benefits, impact, and limitations are discussed.
Dennis Stucke, Sebastian Blauth, Christian Leithäuser, Thomas Grützner   +3 more
wiley   +1 more source

Pick matrix conditions for sign-definite solutions of the algebraic Riccati equation [PDF]

, 2001
We study the existence of positive and negative semidefinite solutions of algebraic Riccati equations (ARE) corresponding to linear quadratic problems with an indefinite cost functional.
Rapisarda, P., Trentelman, H.L., Trentelman, H.L.,, P. Rapisarda, Rapisarda, P, Rapisarda, P.,, H.L. Trentelman, Trentelman, HL, Trentelman, Harry L., Rapisarda, Paolo   +9 more
core   +2 more sources

Coupled heat and mass transfer in reactive parallel‐plate flow: A perturbative Graetz model with modal symmetry and Arrhenius kinetics

The Canadian Journal of Chemical Engineering, EarlyView.
A perturbative Graetz model describes coupled heat and mass transfer in reactive Couette–Poiseuille flow between parallel plates. Viscous dissipation and heat of reaction produce a small temperature rise, which enhances Arrhenius reaction rates and modestly accelerates axial species conversion in the small‐Brinkman‐number regime.
Leonardo Damián Soria Rodríguez, Anthony Albert Harrup Gutiérrez   +1 more
wiley   +1 more source

Rational solitons of wave resonant-interaction models [PDF]

, 2013
Integrable models of resonant interaction of two or more waves in 1+1 dimensions are known to be of applicative interest in several areas. Here we consider a system of three coupled wave equations which includes as special cases the vector nonlinear ...
Degasperis, Antonio, Lombardo, Sara, Lombardo, Sara; id_orcid   +2 more
core   +1 more source

From Biological Mechanisms to Causal Inference: Quantitative Systems Pharmacology and Causal Frameworks in Drug Development

Clinical Pharmacology &Therapeutics, EarlyView.
Digital patients and in silico clinical trials offer new opportunities to advance pharmacological research, clinical development, and regulatory decision‐making by enabling the simulation of treatment effects prior to testing in patients. Among the most promising of these opportunities is the combined use of quantitative systems pharmacology (QSP) and ...
Thomas Klabunde, Ramon Hernandez, Piet H. van der Graaf, Tommaso Andreani   +3 more
wiley   +1 more source

An ALE ESFEM for solving PDEs on evolving surfaces [PDF]

, 2012
Numerical methods for approximating the solution of partial differential equations on evolving hypersurfaces using surface finite elements on evolving triangulated surfaces are presented.
Vanessa Styles (4460662), Styles, Vanessa, Charles Martin Elliott (16042838), Elliott, Charles M.   +3 more
core   +1 more source

Myocardial inflammation is associated with impaired mitochondrial oxidative capacity in ischaemic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1246-1255, April 2025.
Abstract Aims Myocardial inflammation and impaired mitochondrial oxidative capacity are hallmarks of heart failure (HF) pathophysiology. The extent of myocardial inflammation in patients suffering from ischaemic cardiomyopathy (ICM) or dilated cardiomyopathy (DCM) and its association with mitochondrial energy metabolism are unknown.
Julius Borger, Elric Zweck, Constanze Moos, Patrick Horn, Fabian Voß, Heinz‐Peter Schultheiss, Jacob Eifer Møller, Udo Boeken, Hug Aubin, Artur Lichtenberg, Malte Kelm, Michael Roden, Amin Polzin, Ralf Westenfeld, Julia Szendroedi, Daniel Scheiber   +15 more
wiley   +1 more source

Positive singular solutions of a certain elliptic PDE

, 2023
In this thesis, we study the existence of positive singular solutions of a system of partial differential equations on a bounded domain. We first consider the solution of the following problem:\begin{equation} \label{base equation} \left\{ \begin{array}{lr} -\Delta w= | \nabla w|^p& \text{in}~~ B_1 \backslash \{0\},\\ w=0 & \text{on}~~ \partial B_1 ...
openaire   +1 more source