Results 41 to 50 of about 2,937 (188)

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Positive singular solutions of a certain elliptic PDE

Journal of Mathematical Analysis and Applications
In this paper, we investigate the existence of positive singular solutions for a system of partial differential equations on a bounded domain \begin{equation} \label{main equation of the thesis} \left\{ \begin{array}{lr} -Δu = (1+κ_1(x)) | \nabla v |^p & \text{in}~~ B_1 \backslash \{0\},\\ -Δv = (1+κ_2(x)) | \nabla u |^p & \text{in}~~ B_1 ...
openaire   +2 more sources

Convergence and Residual Error Analysis of Unsteady MHD Stagnation Flow Over a Cylindrical Surface With Streamline and Isotherm Visualization

Energy Science &Engineering, EarlyView.
The novelty of the current study is that the unsteady MHD Cross nanofluid model is, for the first time, coupled with the melting heat transfer at the stagnation point over a horizontally extended cylinder in a Darcy–Forchheimer porous medium. This work connects complex rheological behaviors and phase‐change phenomena in a unique way, with the only ...
Fahad Maqbul Alamrani, Ebrahem A. Algehyne, Mounirah Areshi, Muhammad Bilal, Mustafa Bayram, Jihad Younis, Anwar Saeed   +6 more
wiley   +1 more source

Unlocking Hydrokinetic Energy in the Brazilian Amazon: A Statistical Resource Assessment and Economic Feasibility Analysis

Energy Science &Engineering, EarlyView.
This study develops a spatial and technical framework to evaluate hydrokinetic energy potential in the Amazon as a sustainable alternative to diesel‐based systems. By modeling regional resources, we demonstrate that hydrokinetic sources offer a cleaner, economically competitive solution for displacing fossil fuels in remote riverine communities ...
Ana Cláudia Pinto Ferraz, Ivan Felipe Silva dos Santos, Marina Batalini Macedo, Regina Mambeli Barros, Janayna Alves Romil dos Santos   +4 more
wiley   +1 more source

Fluorescence‐Guided Detection of Perineural and Bony Invasion With Margin Correlation in Gingival Squamous Cell Carcinoma Using Panitumumab‐IRDye800

Head &Neck, EarlyView.
ABSTRACT Background Near‐infrared (NIR) fluorescence‐guided surgery using EGFR‐targeted tracers (e.g., panitumumab‐IRDye800CW) can provide real‐time visualization of tumors and margins in Head and Neck Squamous Cell Carcinoma. Prior studies have demonstrated its safety and potential to improve intraoperative decision‐making and margin assessment ...
Makenna Brown, Mabrooka Kazi, Hidenori Tanaka, Brandee Brown, Mitra Mehrad, Sarah Rohde, Eben Rosenthal, Kyle Mannion   +7 more
wiley   +1 more source

Explicit Methods for Inverse Source Identification in Transient Diffusion via Truncated Eigenfunction Regularization of Temperature Measurements

Heat Transfer, EarlyView.
ABSTRACT This work presents and compares two explicit approaches for estimating space‐ and time‐dependent source terms in parabolic diffusion equations, derived from analytical solutions obtained through the Classical Integral Transform Technique (CITT).
André J. P. de Oliveira, Diego C. Knupp, Luiz A. S. Abreu, Mousa J. Huntul, David A. Pelta, Antônio J. da Silva Neto   +5 more
wiley   +1 more source

Exposure‐Based Toxicological Evaluation of Lead and Elemental Impurities in Encapsulated Green Tea Dietary Supplements Under a Regulatory Framework

Journal of Applied Toxicology, EarlyView.
ABSTRACT The consumption of green tea (Camellia sinensis (L.) Kuntze) in the form of encapsulated dietary supplements has increased substantially in recent years; however, data supporting toxicological risk assessment of inorganic contaminants in these products remain limited.
Amanda da Silva Chaves, Lisia Maria Gobbo dos Santos, Beatriz Scaramelo, Júlia Maria Peixoto Loureiro, Fabio Coelho Amendoeira, Silvana do Couto Jacob, Fausto Klabund Ferraris   +6 more
wiley   +1 more source

Coping Practices of Small‐ and Medium‐Sized Enterprises Facing Power Asymmetry in Digital Platform Business

Strategic Change, EarlyView.
ABSTRACT Digital platform (DP) enterprises have risen to the top of the global economy by inverting traditional business models. They earn money through matchmaking, transaction facilitation, and efficient orchestration of other stakeholders' resources.
Lukas R. G. Fitz, Jochen Scheeg
wiley   +1 more source

Traveling Fronts for (q,r)$(q, r)$‐Relativistic Operators: Existence and Asymptotic Properties

Mathematische Nachrichten, EarlyView.
ABSTRACT A new reaction–diffusion model governed by a (q,r)$(q, r)$‐relativistic type diffusion, generalizing the p$p$‐relativistic one and encompassing singular and/or degenerate diffusivity, is introduced. In the monostable case, some existence results for (decreasing) fronts are then provided, exploiting the study of a suitable two‐point problem ...
Pavel Drábek, Maurizio Garrione, Michaela Zahradníková   +2 more
wiley   +1 more source

Nonconstant Positive Steady States for a Predator–Prey System With Signal‐Dependent Diffusion

Mathematische Nachrichten, EarlyView.
ABSTRACT This paper investigates a highly nonlinear predator–prey reaction–diffusion system featuring signal‐dependent prey diffusion, where the motility of the prey is modulated by a chemical signal released by predators. For unbounded functional responses, we establish the global‐in‐time existence and uniform‐in‐time boundedness of classical ...
Qigang Deng, Hao Shen, Ranchao Wu, Hao Wang   +3 more
wiley   +1 more source