Results 51 to 60 of about 2,937 (188)

Optimal Design of Elastic Plates: Hybrid Numerical Method Based on Homogenization and Shape Derivative

Mathematical Methods in the Applied Sciences, EarlyView.
ABSTRACT This paper focuses on optimal design problems in the context of the Kirchhoff‐Love model for pure bending of a thin, solid, symmetric plate under a transverse load. The objective is to simultaneously determine the optimal outer shape of the domain and the distribution of two isotropic materials within the domain in order to minimize compliance.
Ivana Crnjac, Jelena Jankov Pavlović, Petar Kunštek   +2 more
wiley   +1 more source

On the Global Asymptotic Stability of an Infection‐Age‐Structured Competitive Model

Mathematical Methods in the Applied Sciences, EarlyView.
ABSTRACT We investigate an infection‐age‐structured competitive epidemiological model involving multiple strains. While classical results establish competitive exclusion when a unique maximal basic reproduction number exists, we provide here a complete characterization of the asymptotic behavior for an arbitrary number of populations without assuming ...
S. Girel, Q. Richard
wiley   +1 more source

Existence and Stability Analysis of Classical and Fractional‐Order Generalized Brusselator Reaction‐Diffusion System

Mathematical Methods in the Applied Sciences, EarlyView.
ABSTRACT The present work is devoted to establishing existence results and examining the stability properties of solutions associated with a generalized Brusselator reaction–diffusion system in both the classical and fractional‐order settings. The corresponding ODE and PDE formulations are considered to establish the global existence of solutions in ...
Fadia Haouam, Lamia Djebara, Salem Abdelmalek, Mokhtar Kirane   +3 more
wiley   +1 more source

Polyphyllin I Alleviates Alcoholic Liver Disease via Modulation of the Phosphodiesterase 6D–Cyclic Guanosine Monophosphate–Protein Kinase G Axis

Phytotherapy Research, EarlyView.
ABSTRACT Alcoholic liver disease (ALD) is a multifaceted disorder in which oxidative injury, iron‐dependent ferroptosis, steatosis, and inflammation are closely intertwined. Consequently, therapeutic strategies targeting a single pathway often produce limited clinical benefits.
Hongyan Feng, Xuelian Yuan, Yawen Xie, Zhenni Xia, Zhaohui Guo, Xuesong Liu, Rong Li, Wenliang Wang   +7 more
wiley   +1 more source

Adaptive Sliding‐Mode Control of a Perturbed Diffusion Process With Pointwise In‐Domain Actuation

International Journal of Robust and Nonlinear Control, EarlyView.
ABSTRACT A sliding mode–based adaptive control law is proposed for a class of diffusion processes featuring a spatially‐varying uncertain diffusivity and equipped with several point‐wise actuators located at the two boundaries of the spatial domain as well as in its interior.
Paul Mayr, Alessandro Pisano, Stefan Koch, Markus Reichhartinger   +3 more
wiley   +1 more source

Single‐Vesicle Functional Nanophenotyping Reveals Heterogeneous PD‐L1 Accessibility in Triple‐Negative Breast Cancer

Small Methods, EarlyView.
Graphical Abstract. High‐speed atomic force microscopy enables real‐time, label‐free visualization of antibody interactions with individual extracellular vesicles. By quantifying binding frequency and dwell time, this approach reveals functional PD‐L1 accessibility that cannot be inferred from protein abundance alone, uncovering nanoscale heterogeneity
Reon Imakawa, Keesiang Lim, Takeshi Yoshida, Tomoyoshi Yamano, Tsunaki Hongu, Uryo Onishi, Masaharu Hazawa, Toshio Ando, Noriko Gotoh, Rikinari Hanayama, Richard W. Wong   +10 more
wiley   +1 more source

Dopamine: The Essential Bridge Mediating Obstructive Sleep Apnea and Hippocampus‐Dependent Learning and Memory Impairments

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Obstructive sleep apnea is a clinical syndrome that triggers a series of pathophysiologic changes, including disturbed sleep architecture, chronic intermittent hypoxia and hypercapnia, and ultimately severe cognitive dysfunction. The hippocampus plays a key role in various cognitive processes such as learning and memory.
Rui Fan, Tao Li, Yan Yan
wiley   +1 more source

Saline versus alkaline stresses in paddy soils drive divergent microbial nutrient limitations despite shared carbon constraints

Functional Ecology, EarlyView.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Soil salinization and alkalization often suppress microbial functional activity, triggering negative feedback loops in microbial metabolism, degrading nutrients and agricultural productivity.
Yuqi Chen, Lingying Xu, Xu Zhao
wiley   +1 more source

Comparative Genomics and Functional Evidence for Convergent Adaptation to Hypoxia in Mammals

Integrative Zoology, EarlyView.
This study reveals convergent selection in mammals adapted to hypoxia. Functional assays demonstrate that amino acid mutations reduce oxidative stress, attenuate hypoxia‐induced injury, and modulate the hypoxia‐inducible transcription factor (HIF)‐driven hypoxic response.
Hao Dong, Chunxu Wang, Enqing Pei, Liang Zhao, Simin Chai, Ran Tian   +5 more
wiley   +1 more source

Telangiectasia in Systemic Sclerosis Is a Marker of Increased Disease Morbidity and Mortality: Analyses From the Australian Scleroderma Cohort Study

Australasian Journal of Dermatology, EarlyView.
ABSTRACT This Australian retrospective cohort analysis of 1977 patients investigates and expands on correlates of telangiectasia in systemic sclerosis to determine whether this cutaneous sign is a potential surrogate marker for disease progression and prognosis.
Vivien Wai Yun Lai, Dylan Hansen, Maryam Tabesh, Jessica Fairley, Laura Ross, Nava Ferdowsi, Gene‐Siew Ngian, Diane Apostolopoulos, Joanne Sahhar, Lauren V. Host, Jennifer Walker, Gabor Major, Susanna Proudman, Wendy Stevens, Mandana Nikpour, Amanda M. Saracino   +15 more
wiley   +1 more source