Results 41 to 50 of about 98,984 (218)

Analysis of 42 Years of Cosmic Ray Measurements by the Neutron Monitor at Lomnický štít Observatory

Earth and Space Science
The correlation and physical interconnection between space weather indices and cosmic ray flux has been well‐established with extensive literature on the topic.
Imre Kisvárdai, Filip Štempel, Lukáš Randuška, Šimon Mackovjak, Ronald Langer, Igor Strhárský, Ján Kubančák   +6 more
doaj   +1 more source

Exploring the intersection between sustainable finance and achieving carbon neutrality in the transportation sector

Heliyon
In the context of China's transportation sector, which has faced escalating challenges in carbon emissions, this study delves into the intricate nexus between sustainable finance strategies and the imperative of achieving carbon neutrality.
Jingfu Lu, Fatime Gulzar, Yifan Lai
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Rigorous Evaluation of Machine Learning Intrusion Detection for Water Treatment Systems on SWaT Network Traffic

Applied Sciences
Intrusion detection systems (IDSs) for industrial control networks are commonly evaluated using random stratified splits, placing rows from every recorded attack in both training and test sets.
Sebastian Mesca, Emil Pricop, Grigore Stamatescu   +2 more
doaj   +1 more source

The evolutionary dynamics of microRNAs in domestic mammals

Scientific Reports, 2018
MiRNAs are crucial regulators of gene expression found across both the plant and animal kingdoms. While the number of annotated miRNAs deposited in miRBase has greatly increased in recent years, few studies provided comparative analyses across sets of ...
Luca Penso-Dolfin, Simon Moxon, Wilfried Haerty, Federica Di Palma   +3 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Evaluating the Nexus Between Exports, Imports, GDP, and Gross Capital Formation in South Africa

Journal of Enterprise and Development
Purpose: This study evaluates the connection between exports, imports, GDP, and gross capital formation in South Africa. Method: The study employed the AutoRegressive Distributed Lag (ARDL) method, along with unit root tests to validate data ...
Ahmed Oluwatobi Adekunle
doaj   +1 more source

Directions for Optimization of Photosynthetic Carbon Fixation: RuBisCO's Efficiency May Not Be So Constrained After All

Frontiers in Plant Science, 2018
The ubiquitous enzyme Ribulose 1,5-bisphosphate carboxylase-oxygenase (RuBisCO) fixes atmospheric carbon dioxide within the Calvin-Benson cycle that is utilized by most photosynthetic organisms.
Peter L. Cummins, Babu Kannappan, Jill E. Gready   +2 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Genome mining of Streptomyces bambergiensis AC-800 unravels the biosynthetic gene cluster for inhibitors of prolyl hydroxylase fibrostatins

Scientific Reports
Streptomyces bambergiensis AC-800 is known as a producer of moenomycin family antibiotics active against gram-positive bacteria. Complete genome sequencing of S.
Jaime Felipe Guerrero Garzón, Martin Zehl, Olha Schneider, Inmaculada Tocino Marquez, Christian Rückert-Reed, Jörn Kalinowski, Sergey B. Zotchev   +6 more
doaj   +1 more source