Results 51 to 60 of about 99,109 (264)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Spanners of additively weighted point sets

, 2011
We study the problem of computing geometric spanners for (additively) weighted point sets. A weighted point set is a set of pairs (p,r) where p is a point in the plane and r is a real number. The distance between two points (pi,ri) and (pj,rj) is defined
Couture, Mathieu, Prosenjit Bose, Bose, Prosenjit, Mathieu Couture, Carmi, Paz, Paz Carmi   +5 more
core   +1 more source

Random directed and on-line networks [PDF]

, 1999
Various random spatial graphs defined on partially ordered point sets have been treated recently in the literature: these are discussed in the framework of the minimal directed spanning forest.
Betti, Arianna, Saghie Sharifzadeh, Mallon, Ron, Adrian T.H. Kuah, Sandu, Gabriel, Lipscomb, Scott D, Penrose, Mathew, Sims-Schouten, Wendy, Trondalen, Gro, Bauman, Adrian E., Ruetsche, Laura, Gonnelli, Renato, Richard G. Newell, Bull, Fiona C., Del Prete, Fabio, Kelly, Daniel, Pernau, Margrit, Wigram, Tony, Newell, R, Laure Cahen-Maurel, Gold, Christian, Overgaard, Morten, Rouveret, Alain, Andrew R. Wade, Caudal, Patrick, Pernau, M. ; https://orcid.org/, Gebauer, Jochen E., Lau, ALD, Calderone, Basilio, Asendorpf, Jens B., RENAUT, Olivier, Marcello, Ferro, Ugolini, Stefano, Sitaram, R., Sedikides, Constantine, Paolo Mancosu, Crouch, Colin, Mogens Lerke, Kuah, Adrian T. H., Philippe De Brabanter, Miller, Ralph R., Aikhenvald, Alexandra Y., Kiesling, Scott F., Mathew D. Penrose, Morten Overgaard, Arthur C. Bohart, Rogers, K, Gregor Schöner, Battisti, Giuliana, Schoner, G., Leary, Mark R., Laborda, Mario A., Gebel, Klaus, Riley, Sarah, Cummins, RA, Jeanne C. Watson, Watson, Jeanne C., Wade, Andrew R., John Earman, Leslie S. Greenberg, Kristian Rogers, Birbaumer, N., Dobrovie-Sorin, Carmen, Sangkyun Lee, Cristiana R. Lages, Scharpf, F., Finnerty, Paraic Martin, G.A. Ummarino, Max Kistler, Laerke, Mogens, Kuah, Adrian T.H., Bonde, Lars Ole, Ranganatha Sitaram, Christian Gold, Kistler, Max, Grimshaw, Mark Nicholas; id_orcid, Edouard Machery, Lages, Cristiana R., Machery, Edouard, Beyssade, Claire, Mari, Alda, Earman, John, Oudeyer, Pierre-Yves, Vito, Pirrelli, Evelina Dineva, Cahen-Maurel, Laure, Scharpf, Fritz W., Daghero, Dario, Yogesh K. Dwivedi, Thomaidis, Konstantinos, Flandreau, Marc, Ummarino, Giovanni, Marc Flandreau, Robert L. Bryant, Dineva, E., Wade, Andrew, Giuliana Battisti, Betti, A., Penrose, Mathew D., Stefano Ugolini, Dwivedi, Yogesh K., Elliott, Robert, Robert Elliott, Laura Ruetsche, Daniel Kelly, Ron Mallon, Bohart, Arthur C., Lee, S., Crouch, C., McConnell, Bridget L., Bryant, RL, D. Daghero, John P. Spencer, R.S. Gonnelli, Tan, Siu-Lan, Patrick Caudal, Alexandro, Lenci, Spencer, J. P., Mancosu, Paolo, Niels Birbaumer, Tony Wigram, Mikhail Kissine, Greenberg, Leslie S.   +122 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

How does playfulness (re)frame the world? Evidence for selective cognitive and behavioral redirecting in times of adversity

Frontiers in Psychology
IntroductionDo playful people perceive, approach, and respond to their environment and life events differently than less playful individuals? While playfulness has been theorized to affect how individuals frame or reframe situations, this widely accepted
Xiangyou Shen, Zoe Crawley
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Analysis of 42 Years of Cosmic Ray Measurements by the Neutron Monitor at Lomnický štít Observatory

Earth and Space Science
The correlation and physical interconnection between space weather indices and cosmic ray flux has been well‐established with extensive literature on the topic.
Imre Kisvárdai, Filip Štempel, Lukáš Randuška, Šimon Mackovjak, Ronald Langer, Igor Strhárský, Ján Kubančák   +6 more
doaj   +1 more source

Exploring the intersection between sustainable finance and achieving carbon neutrality in the transportation sector

Heliyon
In the context of China's transportation sector, which has faced escalating challenges in carbon emissions, this study delves into the intricate nexus between sustainable finance strategies and the imperative of achieving carbon neutrality.
Jingfu Lu, Fatime Gulzar, Yifan Lai
doaj   +1 more source