Results 101 to 110 of about 156,433 (260)

Plasma Metabolic Profile with Machine Learning Reveals Distinct Diagnostic and Biological Signatures for Pathologic Myopia

open access: yesAdvanced Science, EarlyView.
Plasma metabolic detection combined with machine learning offers a precise (area under the curve of 0.874) and high‐throughput (<30 s) diagnosis for pathologic myopia (serious myopic macular degeneration). The biomarkers indicate the pathologic myopia‐associated systemic metabolic reprogramming, which exhibits specificity for myopic macular ...
Ziheng Qi   +13 more
wiley   +1 more source

Aprendizaje de habilidades para la vida en estudiantes-deportistas: el papel del entrenador

open access: yesRevista de Psicología Aplicada al Deporte y al Ejercicio Físico
El tema de las habilidades para la vida es uno de los más estudiados en los últimos años a raíz de la aplicación de la perspectiva del Positive Youth Development al contexto deportivo.
Irene Checa   +3 more
doaj   +1 more source

MicroRNA‐Enriched Plant‐Derived Exosomes Alleviate Colitis by Modulating Systemic Immunity, Metabolic Homeostasis, and Gut Microbiota

open access: yesAdvanced Science, EarlyView.
Herbal medicine, with its multicomponent and multitarget potential, is often studied primarily for traditional forms, especially phytochemicals. Currently, ulcerative colitis lacks natural, low‐toxicity therapies, yet emerging research highlights plant‐derived exosomes as a promising option.
Ruipeng Shi   +9 more
wiley   +1 more source

Role of parenting attitudes and basic psychological needs in life skills development and transfer among Korean student-athletes

open access: yesScientific Reports
Recent literature on positive youth development through sports has consistently emphasized the role of parents in developing and transferring life skills of athletes. However, related research findings are still lacking, especially within Asia.
Dong-Su Kim, Hyeongho Jin, Junsu Bae
doaj   +1 more source

Regulating PPARG Reduces Lipid Accumulation in Microglia and Promotes Functional Recovery After Spinal Cord Injury

open access: yesAdvanced Science, EarlyView.
Macrophages infiltrate the spinal cord post‐injury, decreasing over time. Microglia phagocytose myelin debris, increasing lipid accumulation. Macrophage deletion improves outcomes, while microglial deletion worsens them. The LD+ microglia subtype shows abnormal Pparg signaling.
Mingran Luo   +17 more
wiley   +1 more source

TWF2 Drives Tumor Progression and Sunitinib Resistance in Renal Cell Carcinoma through Hippo Signaling Suppression

open access: yesAdvanced Science, EarlyView.
Twinfilin actin‐binding protein (TWF2) is upregulated in sunitinib‐resistant renal cell carcinoma (RCC) cells, where it interacts with YAP and protects YAP from degradation. Stabilized YAP translocates into the nucleus and activates transcription of target genes, promoting RCC progression and drug resistance.
Liangmin Fu   +25 more
wiley   +1 more source

Multi‐Habitat Landscape Promotes Microbial Diversity: Insights from the Traditional Agricultural Heritage and the Global Trend

open access: yesAdvanced Science, EarlyView.
The 2500‐year‐old Mulberry‐dyke and Fish‐pond agricultural heritage system reveals how interconnected habitats foster microbial diversity. Multi‐habitat landscapes enhance microbial diversity through cross‐habitat dispersal and adaptive trait convergence. Globally, regions with diverse habitats support a greater diversity of soil microbiomes.
Jintao He   +8 more
wiley   +1 more source

Comprehensive Genetic Map of Muscle Lipidome Reveals Novel Insights Into Flavor Variation in Ruminant Meat

open access: yesAdvanced Science, EarlyView.
Ruminant meat is widely appreciated for its distinctive flavor. Lipids play a central role in influencing meat flavor, yet their genetic and biochemical basis remains largely unexplored. Here, a comprehensive lipid genetic map of sheep muscle is constructed and 20 candidate genes potentially modulating lipid levels are identified to provide a roadmap ...
Xueying Zhang   +17 more
wiley   +1 more source

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