Results 121 to 130 of about 167,379 (299)

A Deep Representation Learning Method for Quantitative Immune Defense Function Evaluation and Its Clinical Applications

Advanced Science, EarlyView.
ImmuDef, a novel algorithm to quantitatively evaluate the anti‐infection immune defense function of an individual based on RNA‐seq data via a variational autoencoder (VAE) model. It is validated on 3200+ samples across four immune states with high accuracy. It can serve as a metric for disease severity and prognosis across pathogenic cohorts.
Zhen‐Lin Tan, Tao Luo, Yu Lin, Xiao‐Jun Wu, Wen‐Kang Shen, Jie Chen, Qian Lei, An‐Yuan Guo   +7 more
wiley   +1 more source

Special Section Introduction: Thriving in Context: Findings from the 4-H Study of Positive Youth Development [PDF]

, 2012
G. John Geldhof, Edmond P. Bowers, Richard M. Lerner   +2 more
openalex   +1 more source

Trajectories of positive youth development and promotive factors among adolescents during the transition to high school in China [PDF]

, 2023
Xiaoyun Chai, Peng Xiong, Danhua Lin
openalex   +1 more source

DNMT2‐m5C‐ACLY Axis Promotes Lenvatinib Resistance in Hepatocellular Carcinoma Through Histone Acetylation‐Mediated Notch Pathway

Advanced Science, EarlyView.
Lenvatinib resistance poses a major challenge in advanced hepatocellular carcinoma (HCC). This study reveals that DNMT2 upregulation is a key driver, which stabilizes ACLY mRNA via m5C modification and activates the Notch signaling pathway. Crucially, combining ACLY inhibitors with lenvatinib overcomes resistance and suppresses tumors, offering a ...
Shiguang Yang, Jie Li, Shengwei Mao, Xuhui Zhao, Douwaner Liu, Jiafeng Chen, Jialu Fu, Yichao Bu, Xiaoling Wu, Shaoqing Liu, Qifeng Yu, Qiongzhu Dong, Zheng Tang, Yuan Fang, Yinghong Shi   +14 more
wiley   +1 more source

Multi‐Dimensional Acoustic Cascaded Holographic Encryption with Instantaneous Visual Decryption via Particle Manipulation

Advanced Science, EarlyView.
Acoustic holograms act as key tools for information encryption, yet current schemes limit encryption dimensionality/security and require time‐consuming decryption. A compact device integrates multi‐dimensional cascaded acoustic holography with particle manipulation, employs extra secret keys, enables rapid decryption, and is validated via 1D/2D/3D ...
Qin Lin, Feiyan Cai, Yunqing Liu, Zejiao Zhou, Jiayang Li, Rujun Zhang, Hongpeng Chen, Hairong Zheng, Huailing Zhang   +8 more
wiley   +1 more source

Deuteration Induced Electron‐Phonon Coupling Modulation: Suppressing Energy Dissipation and Enhancing Carrier Separation in Organic Photocatalysis

Advanced Science, EarlyView.
During charge transport, photogenerated carriers exchange energy with lattice vibrations, influencing photocatalytic performance. The deuteration strategy enhances exciton dissociation and suppresses non‐radiative energy loss, significantly improving photocatalytic hydrogen evolution.
Hongli Sun, Zirui Zhou, Yunfei Ma, Qingzhu Xu, Yanglong Liao, Cheng Han, Yue Zheng, Xiaosong Cao, Yu Wang, Zutao Fan, Jianfeng Zhao, Chenliang Su, Fengtao Fan, Bin Liu   +13 more
wiley   +1 more source

Secondary Data Analyses of Conclusions Drawn by the Program Implementers of a Positive Youth Development Program in Hong Kong [PDF]

, 2010
Andrew M. H. Siu, Daniel T. L. Shek
openalex   +1 more source

Alternative Pathway for Methyl Supply through the Coupling of SHMT1 and PEMT to Maintain Astrocytic Homeostasis in Parkinson's Disease

Advanced Science, EarlyView.
In Parkinson's disease, SHMT1 downregulation disrupts its interaction with PEMT in astrocytes, reducing SAM levels. This leads to H3K4me1 hypomethylation and decreased Slc1a2/Glul expression, ultimately exacerbating neuroexcitotoxicity and dopaminergic neuron loss.
Yue‐Han Chen, Rong‐Xin Zhu, Nuo‐Xi Zhang, Ting‐Ting Sun, Xi‐Wei Zhang, Yu‐Jie Zhao, Ben‐Yu He, Hang Yao, Ren‐Hong Du, Lei Cao, Wen‐Bin Zhang, Wei‐Guo Liu, Yun Cai, Cong Wang, Gang Hu, Yao Wei, Yang Liu, Ming Lu   +17 more
wiley   +1 more source

Physical Activity and Positive Youth Development: Impact of a School-Based Program

, 2011
Kristine A. Madsen, Katherine A. Hicks, Hannah R. Thompson   +2 more
openalex   +2 more sources

The Gut Commensal Butyricimonas Virosa Modulates Gut Microbiota‐Dependent Thiamine Metabolism and Attenuates Mouse Steatotic Liver Disease

Advanced Science, EarlyView.
This study reveals that dietary stachyose enriches Butyricimonas virosa, effectively attenuating metabolic dysfunction‐associated steatotic liver disease (MASLD). Mechanistically, B. virosa enhances gut thiamine monophosphate synthesis, which elevates hepatic thiamine pyrophosphate levels.
Ningning He, Haoyu Wang, Zizhen Yang, Hui Li, Bei Liu, Kaiwei Chen, Zhinan Wu, Xinnan Zhao, Hewei Liang, Mengmeng Wang, Xiaofang Li, Yiyi Zhong, Haifeng Zhang, Liang Xiao, Karsten Kristiansen, Jixing Peng, Yuanqiang Zou, Shangyong Li   +17 more
wiley   +1 more source