Results 61 to 70 of about 19,416,993 (261)

UDP‐Glucose‐6‐Dehydrogenase Mediated O‐GlcNAcylation of Tight Junction Protein 1 Suppresses Metastasis in Renal Cell Carcinoma

Advanced Science, EarlyView.
Our research unveiled a regulatory paradigm wherein TRIM25 orchestrates the ubiquitin‐mediated degradation of UGDH. UGDH modulates the protein stability of TJP1 by regulating O‐GlcNAcylation levels, effectively impeding the metastasis of ccRCC. Our insights elevate UGDH to a pivotal biomarker and tumor suppressor, marking the first demonstration that ...
Xiaolin Chen, Yuhang Bao, Tao Liu, Jianhui Qiu, Yuanyuan Ma, Zedan Zhang, Chuandong Wang, Ruiyi Deng, Zheng Song, Tianyi He, Haode Liu, Jingcheng Zhou, Yizhou Wang, Kan Gong   +13 more
wiley   +1 more source

The mediating role of the 5Cs of PYD in the relationship between grit and academic adjustment in Spanish undergraduates

Frontiers in Education
IntroductionAcademic success paves the way for positive youth (and adult) development, leading to short- and long-term positive outcomes. In the case of Spain, research has identified the need to pay closer attention to youth academic performance and ...
Diego Gomez-Baya, Ana Kozina, Jet Uy Buenconsejo, José Antonio Muñiz-Velázquez   +3 more
doaj   +1 more source

Self determination as a positive youth development construct: Conceptual bases and implications for curriculum development

, 2006
This paper outlines the conceptualization of self-determination from the perspectives of motivation, skills enhancement and positive youth development.
Tsang, SKM, Sandra KM Tsang, Eadaoin KP Hui, Hui, EKP   +3 more
core   +1 more source

Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer

Advanced Science, EarlyView.
The mechanisms of SeNPs therapy in cancer treatment, encompass three parallel actions: (1) seleno‐amino acids, key metabolites, upregulate GPX2 expression, thereby inhibiting tumor metastasis via the GPX2‐HIF1α‐VEGF signaling pathway; (2) selenite (SeO32−), an inorganic metabolite, forms hydrogen bonds with amino acid residues 13–17 of the KRAS G13D ...
Xiaoting Liu, Chong Wu, Shiyao Song, Li Ma, Shaoqing Huang, Yuting He, Qinghai Li, Yanzhou Chang, Dan Jiang, Yong Mei, Junchao Cai, Zhenshuang Du, Tianfeng Chen, Weiling He   +13 more
wiley   +1 more source

Identity Development in Adolescence: Implications for Youth Policy and Practice

Adolescents experience several developmental transitions involving physical growth, advances in cognition (thinking), and increased expectations from society.
Lambouths, Danny L, Schwartz, Seth J, Chico, Emilia, Xing, Kuan, Brittian, Aerika S   +4 more
core   +1 more source

Synergistic Spin‐Polarization and Single‐Atom Engineering in Magnetic Heterojunctions for Efficient Solar Water Splitting

Advanced Science, EarlyView.
High‐throughput screening led to the identification of 67 Z‐scheme heterojunctions (comprising 2D magnetic transition metal halides and non‐magnetic transition metal chalcogenides). For CrI3/MoTe2 and CrI3/WTe2, electronic structure analysis demonstrated that synergistic crystallographic point group and built‐in electric field effects generate a ...
Hongyang Ren, Zhenzhou Guo, Huirong Wu, Peilin Huang, Jie Yang, Jie Zhang, Guangqian Ding, Hongkuan Yuan, Biao Wang   +8 more
wiley   +1 more source

Today's youth, tomorrow's workforce: reengaging unemployed and opportunity youth in Oregon [PDF]

, 2016
by Cord Bueker, Jr., Workforce Policy Analyst, Youth Development Council.Title from PDF caption (viewed on June 30, 2020).This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program.

core  

Toward Prostate Cancer Early Warning with a Self‐Powered Wearable Biosensing Platform Integrated with Machine Learning

Advanced Science, EarlyView.
ABSTRACT Current prostate cancer detection methods remain limited in non‐invasiveness and specificity, prompting interest in urinary biomarkers such as sarcosine. Here, we report a urine‐powered wearable platform for non‐invasive sarcosine detection as a proof‐of‐concept for decentralized early warning.
Jing Xu, Hanxiao Chen, Qichen Yuan, Liucun Yin, Yifang Tao, Hong Wang, Yuquan Xue, Delai Fu, Huan Pang, Tie Chong, Li Xue   +10 more
wiley   +1 more source

The Pursuit of Social Justice Through Sport for Development Organizations in the United States

Youth
While Sport for Development (SfD) scholars have deconstructed the interplay between global development discourse, policy, funding, practice, and local agency, SfD organizations in the Global North have yet to be deconstructed with the same intensity ...
Meredith A. Whitley
doaj   +1 more source

Two‐Dimensional Triferroics: From Fundamental Couplings to Multifunctional Applications

Advanced Science, EarlyView.
This graphic summarizes the three main types of currently reported 2D triferroic couplings. From the structural perspective, existing systems can be broadly classified into two categories, which exhibit distinct symmetry features and coupling behaviors. Beyond the lattice difference, a third type involves the interplay among ferroelectricity, magnetism,
Yang Li, Jialin Gong, Zhiqing Li
wiley   +1 more source