Results 101 to 110 of about 160,506 (330)

AUGUSTE COMTE’S POSITIVISM

open access: yesKanz Philosophia: A Journal for Islamic Philosophy and Mysticism
Islamic education encompasses not only worship but included in it is the aspect of using reason to understand God's creation and how the universe works. Science continues to develop and requires humans to be able to adapt to developments over time. Comte'
Yudha Okta Anuhgra
doaj   +1 more source

Mishpat Ivri, Halakhah and Legal Philosophy: Agunah and the Theory of “Legal Sources" [PDF]

open access: yes, 2001
In this paper, I ask whether mishpat ivri (Jewish Law) is appropriately conceived as a “legal system”. I review Menachem Elon’s use of a “Sources” Theory of Law (based on Salmond) in his account of Mishpat Ivri; the status of religious law from the ...
Jackson, Bernard S.
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Antiantipositivism: Of Epistemological Hypochondria, Constitutional Otherness, and Other Demons

open access: yesEtnoantropološki Problemi
Anthropology was quite loud in proclaiming its own epistemological hypochondria. In this paper, we propose an unconventional methodological bricolage of philosophy of science, contextualistic anthropology and structural-semiological analysisderived from ...
Nina Kulenović
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

Republican Monsters: The Cultural Construction of American Positivist Criminology, 1767-1920 [PDF]

open access: yes, 2019
This dissertation examines the history of and cultural influences on positivist criminology in the United States. From Benjamin Rush to the present day, the U.S.
Burton, Chase Smith
core  

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Natural Law as Professional Ethics: A Reading of Fuller [PDF]

open access: yes, 2000
In Plato\u27s Laws, the Athenian Stranger claims that the gods will smile only on a city where the law is despot over the rulers and the rulers are slaves of the law.
Luban, David
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

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