Results 111 to 120 of about 160,506 (330)

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

SOBRE POSITIVISMO E EDUCAÇÃO

open access: yesRevista Diálogo Educacional, 2002
This paper presents a reflection upon education according to the positivist philosophy particularly based on Comet's ideas. It starts out with an introduction about the emergence of the positivist philosophy and follows on with the topics "positivism ...
Jamil Ibrahim Iskandar, Maria Rute Leal
doaj  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Review of Post-Theory: Reconstructing Film Studies, edited by David Bordwell and Noël Carroll (Madison, Wisconsin: the University of Wisconsin Press, 1996) [PDF]

open access: yes, 1997
A review of Post-Theory: Reconstructing Film Studies, edited by David Bordwell and Noël Carroll (Madison, Wisconsin: the University of Wisconsin Press, 1996), xviii & 564 pages, $45.00 cloth, $17.95 paper, published on pages 492-494 of Philosophy ...
Cameron, Evan Wm.
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Siting Foreign Law: How Derrida Can Help [PDF]

open access: yes, 2011
Secondary spectrum access to TV white spaces is considered as a promising solution to relieve the spectrum shortage. In Europe, SE43 working group in CEPT is leading the discussion on the technical requirements for exploiting TV white spaces through the ...
Shi, Lei, Sung, Ki Won, Zander, Jens
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

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