Results 111 to 120 of about 153,438 (339)
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Legal Positivism: Its Scope and Limitations.
, 1966 Robert S. Summers, Samuel I. Shuman
openalex +2 more sources
Determination of competency framework for technical and vocational education and training (TVET) educators in Nigerian tertiary institutions [PDF]
, 2018 Lack of competent TVET Educators in Nigerian institutions has led to several problems such as low quality graduates and unemployment. Competency is a vital element for assessing the quality of technical and vocational education and training (TVET ...
Adamu, Mohammed Hamisu
core +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
Revista Diálogo Educacional, 2002 This paper presents a reflection upon education according to the positivist philosophy particularly based on Comet's ideas. It starts out with an introduction about the emergence of the positivist philosophy and follows on with the topics "positivism ...
Jamil Ibrahim Iskandar, Maria Rute Leal
doaj
Liberalism, positivism and patriotism of Vladimir Jovanovic [PDF]
, 2012 Boris Milosavljević
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EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines
Molecular Oncology, EarlyView.The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche +8 more
wiley +1 more source
EKSISTENSI PERADILAN TATA USAHA NEGARA DALAM MEMBERIKAN KEADILAN ADMINISTRATIF TERHADAP PENCARI KEADILAN [PDF]
, 2014 Administrative courts are one of the implementing judicial authority that examine, hear and decide disputed in the administrative field. They are expected to uphold the law and justice against those seeking justice.
LAZIRA, FATIATULO
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