Results 41 to 50 of about 20,222 (228)
Positivism as a Dis/Utopia and Alternative Scientific Approaches
Ankara Üniversitesi Dil ve Tarih-Coğrafya Fakültesi Dergisi, 2018 Although positivism, based on linear progress and the idea that social development can only be achieved through scientific developments, put forward by Auguste Comte as a science movement against idols such as Baconian utopia, it has been argued that it ...
Ezgi Ece ÇELİK
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The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
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Post-Positivism as a Research Approach in Public Law [PDF]
Faṣlnāmah-i Pizhūhish-i Huqūq-i ̒UmūmīIntroductionThe importance of research methodology is already highlighted, as the validity of knowledge depends on aligning the research design and methodology with dominant paradigms.
Ayat Mulaee, Nusratullah Nabeel Rahimi
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pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
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FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
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The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
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Positivism and Totalitarianism
, 2021 This is the version of record of a chapter authored by David Dyzenhaus, and published by the Cambridge University Press.Dyzenhaus argues that Hart’s defence of legal positivism fails because Hart cannot without contradiction espouse both the claim that ...
David Dyzenhaus, Dyzenhaus, David
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Diponegoro Law Review, 2020 The development of legal science and law enforcement is one of the main issues in many countries. The focus of this writing is positivism and its implication towards legal science and law enforcement.
Yusriyadi Yusriyadi
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Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
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5½ Problems with Legal Positivism and Tax Law
, 2017 This essay is a reply to the famous paper by John Gardner: Legal Positivism: 5½ Myths and the more recent paper by John Prebble: Kelsen, the Principle of Exclusion of Contradictions, and General Anti-Avoidance Rules.
Bogenschneider, Bret
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