Results 51 to 60 of about 20,222 (228)
From digital positivism and administrative big data analytics towards critical digital and social media research! [PDF]
, 2017 This essay argues for a paradigm shift in the study of the Internet and digital/social media. Big data analytics is the dominant paradigm. It receives large amounts of funding, is administrative and a form of digital positivism.
Fuchs, Christian
core +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
International Legal Positivism
, 2022 International audienceThis chapter aims at shedding light on the curious roles performed by the idea of international legal positivism in international legal thought.
d'Aspremont, Jean
core
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
, 2018 Positivism and the critique of positivism becomes an issue in the history of critical theory on two occasions: first, in the 1930s, when Horkheimer and Adorno enter into a discussion with the Vienna Circle of logical positivism, and later in the 1960s ...
Ramsay, Anders,
core
The essay gives an overview of the most important meanings of the expression "legal positivism" and the main forms of legal positivism that can be found in the analytical jurisprudence of civil law area. In particular, the relationship between positivism
Giovanni Battista Ratti +1 more
core +1 more source
Problemos, 2008 Straipsnyje nagrinėjama pozityvizmo ir marksizmo santykio problema. Siekiama išryškinti jų ištakas, sąveiką, panašumus ir skirtumus, parodyti, kad klasikinis marksizmas nėra toks tolimas klasikiniam pozityvizmui, kaip paprastai manoma.
Evaldas Nekrašas
doaj +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Positivism before Logical Positivism in Nordic Philosophy
, 2010 The concept of “style of thought” or Denkstil is today probably primarily associated with the Polish microbiologist and philosopher of science Ludwik Fleck and his writings from the 1930s. It was however used quite extensively already by Karl Mannheim in
Heidegren, Carl-Göran, +1 more
core +2 more sources