Results 71 to 80 of about 153,438 (339)

Survival ‘Beyond Positivism?’

open access: yesPolitikon, 2016
In the late 1980s, Robert Keohane argued that “the greatest weakness of the reflective school of international relations lies not in deficiencies in their critical arguments but in the lack of a clear reflective program that could be employed by ...
Cagla Luleci, I. Erkam Sula
doaj   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

open access: yesFEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue   +6 more
wiley   +1 more source

The decline of Inclusive Legal Positivism [PDF]

open access: yes, 2013
Este trabajo busca dilucidar si el positivismo incluyente logra renovar la tradición del positivismo jurídico o si, por el contrario, es un reflejo de su decadencia.
Etcheverry, Juan Bautista
core  

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

open access: yesFEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello   +6 more
wiley   +1 more source

The role of philosophical context in the development of research methodology and theory [PDF]

open access: yes, 2008
The research strategy dictates the major direction of the research and constitutes one of the important decisions made by the researcher. However, researchers’ understanding on theory at the outset of the research guides the design of the research.
Amaratunga, RDG   +2 more
core  

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

open access: yesMolecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Notes on social and religious positivism [PDF]

open access: bronze, 1987
Amadeu José de Carvalho Homem
openalex   +1 more source

“Beyond Standard Legal Positivism and ‘Aggressive’ Natural Law: Some Thoughts on Judge’ O’Scannlain’s ‘Third Way’” [PDF]

open access: yes, 2011
With his contribution on "The Natural Law in the American Tradition," Judge Diarmuid O'Scannlain has begun the indispensable task of laying the groundwork for sound jurisprudential reasoning in the natural law tradition.
Baur, Michael
core  

Home - About - Disclaimer - Privacy