Results 101 to 110 of about 548,121 (295)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

A family of positive nonstandard numerical methods with application to Black-Scholes equation [PDF]

Sahand Communications in Mathematical Analysis, 2017
Nonstandard finite difference schemes for the Black-Scholes partial differential equation preserving the positivity property are proposed. Computationally simple schemes are derived by using a nonlocal approximation in the reaction term of the Black ...
Mohammad Mehdizadeh Khalsaraei, Nashmil Osmani   +1 more
doaj  

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Positivity-Preserving Rational Cubic Fractal Interpolation Function Together with Its Zipper Form

Axioms
In this paper, a novel class of rational cubic fractal interpolation function (RCFIF) has been proposed, which is characterized by one shape parameter and a linear denominator.
Shamli Sharma, Kuldip Katiyar, Gadug Sudhamsu, Manjinder Kaur Wratch, Rohit Salgotra   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

A positivity preserving and oscillation-free entropy stable discontinuous Galerkin scheme for the reactive Euler equations [PDF]

The reactive Euler equations are a basic model for fluid flows with chemical reactions. In this work, we construct a high order positivity preserving and oscillation-free entropy stable discontinuous Galerkin (DG) scheme for the reactive Euler equations.
Zhao, Weifeng, Lin, Ping, Zuo, Hujian
core   +1 more source

Finite element approximation of a nonlinear cross-diffusion population model [PDF]

, 2003
We consider a fully discrete finite element approximation of the nonlinear cross-diffusion population model: Find u i, the population of the ith species, i = 1 and 2, such that ∂ui ∂t −Δ [ ci ui + ai u2i + ui uj] − bi ∇.
John W. Barrett, Blowey, J.F., James F. Blowey, Blowey, JF, Barrett, J.W., John W. Barrett, Barrett, JW   +6 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

An Inexact Noda Iteration for Computing the Smallest Eigenpair of a Large, Irreducible Monotone Matrix

Mathematics
In this paper, we introduce an inexact Noda iteration method featuring inner and outer iterations for computing the smallest eigenvalue and corresponding eigenvector of an irreducible monotone matrix.
Ching-Sung Liu
doaj   +1 more source

Positivity Preserving Gradient Approximation with Linear Finite Elements [PDF]

Computational Methods in Applied Mathematics, 2018
Abstract Preserving positivity precludes that linear operators onto continuous piecewise affine functions provide near best approximations of gradients. Linear interpolation thus does not capture the approximation properties of positive continuous piecewise affine functions.
openaire   +1 more source