Results 121 to 130 of about 548,121 (295)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Privacy-Preserving Profiling

, 2011
With the rise of social networking, and other sites which collect vast amounts of user data, the issue of user privacy has never been more important. When creating user profiles care must be taken to avoid collecting sensitive information, while ensuring
Barnard, Thomas, Prugel-Bennett, Adam
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Comparative study of high-order positivity-preserving WENO schemes [PDF]

, 2012
In gas dynamics and magnetohydrodynamics flows, physically, the density ρ and the pressure p should both be positive. In a standard conservative numerical scheme, however, the computed internal energy is obtained by subtracting the kinetic energy from ...
Kotov, D. V., Yee, Helen C., Sjögreen, Bjorn   +2 more
core  

POSITIVITY PRESERVING INTERPOLATION BY USING RATIONAL CUBIC BALL SPLINE

, 2016
This paper discusses the positivity preserving by using rational cubic Ball interpolant of the form cubic/quadratic with two parameters. The sufficient condition for the positivity is derived on one parameter meanwhile the other one is a free parameter ...
Abdul Karim, Samsul Ariffin
core   +2 more sources

Artificial Intelligence–Assisted Fractional Nonstandard Finite Difference Scheme for a Noncommensurate Quarantine Reaction–Diffusion Epidemic Model

International Journal of Differential Equations
This paper develops a noncommensurate time-fractional SEIQR reaction–diffusion model for infectious disease dynamics with artificial intelligence (AI)–assisted inverse identification and forecasting.
Younes Brahim Oumedjber, Adel Ouannas, Nadjette Debbouche, Giuseppe Grassi   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Unconditional positivity-preserving and energy stable schemes for a reduced poisson-nernst-planck system

, 2020
The Poisson-Nernst-Planck (PNP) system is a widely accepted model for simulation of ionic channels. In this paper, we design, analyze, and numerically validate a second order unconditional positivity-preserving scheme for solving a reduced PNP system ...
Maimaitiyiming, Wumaier, Liu, Hailiang
core   +1 more source

Positivity-preserving discontinuous Galerkin scheme for linear hyperbolic equations with characteristics-informed augmentation

Results in Applied Mathematics
This paper presents a positivity-preserving discontinuous Galerkin (DG) scheme for the linear hyperbolic problem with variable coefficients on structured Cartesian domains.
Maurice S. Fabien
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source