Results 131 to 140 of about 548,121 (295)

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

A positivity-preserving adaptive-order finite-difference scheme for GRMHD [PDF]

We present an adaptive-order positivity-preserving conservative finite-difference scheme that allows a high-order solution away from shocks and discontinuities while guaranteeing positivity and robustness at discontinuities.
Kim, Yoonsoo, Kidder, Lawrence E., Hébert, François, Teukolsky, Saul A., Deppe, Nils, Throwe, William, Vu, Nils L., Bonilla, Marceline S., Scheel, Mark A.   +8 more
core  

A Computational Modeling for Semi-Coupled Multiphase Flow in Atmospheric Icing Conditions

Journal of Aerospace Technology and Management, 2015
A two-dimensional second-order positivity-preserving finite volume upwind scheme is developed for a semi-coupled algorithm involving the air and droplet flow fields in the Eulerian frame in which shares the grid for each phase.
SungKi Jung
doaj  

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Positivity Preserving Numerical Schemes For Lubrication-Type Equations

, 1998
. Lubrication equations are fourth order degenerate diffusion equations of the form h t + r \Delta (f(h)r\Deltah) = 0, describing thin films or liquid layers driven by surface tension. Recent studies of singularities in which h ! 0 at a point, describing
L. Zhornitskaya, A.L. Bertozzi
core  

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Entropy dissipative higher order accurate positivity preserving time-implicit discretizations for nonlinear degenerate parabolic equations [PDF]

We develop entropy dissipative higher order accurate local discontinuous Galerkin (LDG) discretizations coupled with Diagonally Implicit Runge–Kutta (DIRK) methods for nonlinear degenerate parabolic equations with a gradient flow structure.
Xu, Yan, Van der Vegt, J. J.W.; id_orcid, Xia, Yinhua, Yan, Fengna   +3 more
core   +1 more source