Results 101 to 110 of about 375,391 (267)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Stability and bifurcation analysis in a predator prey model involving additive Allee effect
Revista IntegraciónIn this paper we study codimension 1 Hopf bifurcation for a two dimensional autonomous nonlinear ordinary differential equations system, modeling a predator-prey interaction with Holling type II functional response and additive Allee effect in the prey ...
Jocirei Dias Ferreira +2 more
doaj
Transport equation for growing bacterial populations (I)
Electronic Journal of Differential Equations, 2012 This work deals with a mathematical study for growing a bacterial population. Each bacterium is distinguished by its degree of maturity and its maturation velocity. Here we study the limit case corresponding to infinite maturation velocities. We show
Mohamed Boulanouar
doaj
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Existence of global solutions for systems of reaction-diffusion equations on unbounded domains
Electronic Journal of Differential Equations, 2002 We consider, an initial-value problem for the thermal-diffusive combustion system $$displaylines{ u_t=aDelta u-uh(v) cr v_t=bDelta u+dDelta v+uh(v), }$$ where $a>0$, $d>0$, $beq 0$, $xin mathbb{R}^n$, $ngeq 1$, with $h(v)=v^m$, $m$ is an even nonnegative
Salah Badraoui
doaj
Comput. Artif. Intell., 1996 Summary: A new type of grammar colony is introduced. Its individual components have some features of recognizing machines, nevertheless it is a generative system. The name `colonies with position' is proposed for it. The class \({\mathcal L}_{col_P (1)}\) of languages generated by a single component, as well as the class generated by colonies of such ...
openaire +2 more sources
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source