Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Existence of global solutions for systems of reaction-diffusion equations on unbounded domains
Electronic Journal of Differential Equations, 2002 We consider, an initial-value problem for the thermal-diffusive combustion system $$displaylines{ u_t=aDelta u-uh(v) cr v_t=bDelta u+dDelta v+uh(v), }$$ where $a>0$, $d>0$, $beq 0$, $xin mathbb{R}^n$, $ngeq 1$, with $h(v)=v^m$, $m$ is an even nonnegative
Salah Badraoui
doaj
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
The time interval from amyloid to tau PET positivity varies by age, sex and APOE-ε4 status. [PDF]
J Prev Alzheimers DisMilà-Alomà M +6 more
europepmc +1 more source
Comput. Artif. Intell., 1996 Summary: A new type of grammar colony is introduced. Its individual components have some features of recognizing machines, nevertheless it is a generative system. The name `colonies with position' is proposed for it. The class \({\mathcal L}_{col_P (1)}\) of languages generated by a single component, as well as the class generated by colonies of such ...
openaire +2 more sources
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Diagnostic performance of intraoperative urine dipstick testing during ureteroscopy: association with culture positivity and severe infection. [PDF]
UrolithiasisGonzález González C +6 more
europepmc +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Prediction of immune-related adverse events in urological cancer during checkpoint inhibitor immunotherapy through immunohistochemical analysis of tumorous LCP1/ADPGK. [PDF]
Transl OncolXu L +10 more
europepmc +1 more source