Results 71 to 80 of about 375,391 (267)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Nonnegativity, stability analysis of linear discrete-time positive descriptor systems: an optimization approach [PDF]
Bulletin of the Polish Academy of Sciences: Technical Sciences, 2018 H. Yang, M. Zhou, M. Zhao, P. Pan
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Journal of Causal InferenceThe positivity assumption is central in the identification of a causal effect. Especially its stochastic variant is an issue many applied researchers face.
Ring Katharina, Schomaker Michael
doaj +1 more source
The Best of All Possible Ends of the World: An Interview with Andrew Culp
Lateral, 2018 (University of Minnesota Press, 2016) appears as an anomaly in English Deleuze scholarship. Andrew Culp contrasts Deleuze as a thinker of positivity who constantly demands we find “reasons to believe in this world” with a Deleuze of dark negativity.
Josef Thorne
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
الاختلاف في الإيجاب والقبول مستل من رسالة دكتوراه بعنوان: الفقه الافتراضي في أحكام المعاملات المالية وأثره في النوازل المعاصرة من خلال كتاب فتح القدير لابن الهمام (المتوفى: 861هـ) دراسة فقهية مقارنة [PDF]
Maǧallaẗ Kulliyyaẗ Dar Al-ʿulūm - Ǧāmiʿaẗ Al-Fayūmدار هذا البحث حول مسألة البيع علي شرطين وتوصل البحث إلي : أن الفقهاء اختلفوا في هذه المسألة علي أربعة أقوال : القول الأول: أنهما يتحالفان، فإذا تحالفا فسخ البيع.القول الثاني: أن القول قول المشتري. القول الثالث: يتحالفان إن كان الاختلاف قبل القبض، وإن كان
مرزوق محمد قرني حسين
doaj +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source